Source:http://linkedlifedata.com/resource/pubmed/id/16011982
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0002085,
umls-concept:C0019721,
umls-concept:C0030705,
umls-concept:C0043117,
umls-concept:C0087111,
umls-concept:C0456387,
umls-concept:C0850666,
umls-concept:C0871261,
umls-concept:C0936012,
umls-concept:C1704387,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1707520,
umls-concept:C2911692
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| pubmed:issue |
5
|
| pubmed:dateCreated |
2005-7-13
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| pubmed:abstractText |
Many authors have recently found a positive correlation between Helicobacter pylori infection and idiopathic thrombocytopenic purpura (ITP), the most common autoimmune hematological disorder. In order to clarify the pathogenic mechanism of H. pylori-associated ITP, we have investigated 52 consecutive ITP adult patients for Helicobacter pylori infection, B- and T-cell clonality and HLA class II alleles. Thirty-four ITP patients (65.4%) were infected by H. pylori and bacterium eradication was accompanied by a long-term platelet response in 17 (53.1%) of them. A B-cell clonality was found in three patients (5.8%, two patients H. pylori-negative and one patient H. pylori-positive). The ITP patients with H. pylori infection showed a HLA-DRB1*11, *14 and -DQB1*03 frequencies significantly higher and a -DRB1*03 frequency significantly lower than in H. pylori-negative patients. Moreover, an HLA-DQB1*03 pattern was associated with a higher probability of platelet response to eradication treatment. If our study documents the efficacy of eradication treatment in H. pylori-infected ITP patients, it may also help to identify different subgroups of ITP patients with probably different pathogeneses of thrombocytopenia and, finally, different responses to eradication treatment.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0953-7104
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| pubmed:author |
pubmed-author:ArenaSilviaS,
pubmed-author:De MatteisGiovannaG,
pubmed-author:FedericiFrancescaF,
pubmed-author:FranchiniMassimoM,
pubmed-author:GaioMonicaM,
pubmed-author:GuizzardiElisabettaE,
pubmed-author:PontieroPatriziaP,
pubmed-author:RicettiMaria MMM,
pubmed-author:SoleroPietroP,
pubmed-author:VeneriDinoD,
pubmed-author:ZanusoCarlaC
|
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
307-11
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| pubmed:meshHeading |
pubmed-meshheading:16011982-Adult,
pubmed-meshheading:16011982-Aged,
pubmed-meshheading:16011982-Alleles,
pubmed-meshheading:16011982-B-Lymphocytes,
pubmed-meshheading:16011982-Clone Cells,
pubmed-meshheading:16011982-Female,
pubmed-meshheading:16011982-Genes, MHC Class II,
pubmed-meshheading:16011982-HLA-DQ Antigens,
pubmed-meshheading:16011982-HLA-DR Antigens,
pubmed-meshheading:16011982-Helicobacter Infections,
pubmed-meshheading:16011982-Helicobacter pylori,
pubmed-meshheading:16011982-Humans,
pubmed-meshheading:16011982-Male,
pubmed-meshheading:16011982-Middle Aged,
pubmed-meshheading:16011982-Platelet Count,
pubmed-meshheading:16011982-Polymerase Chain Reaction,
pubmed-meshheading:16011982-Purpura, Thrombocytopenic, Idiopathic,
pubmed-meshheading:16011982-T-Lymphocytes
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| pubmed:year |
2005
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| pubmed:articleTitle |
Analysis of B- and T-cell clonality and HLA class II alleles in patients with idiopathic thrombocytopenic purpura: correlation with Helicobacter pylori infection and response to eradication treatment.
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| pubmed:affiliation |
Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia, Università di Verona.
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| pubmed:publicationType |
Journal Article
|