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rdf:type |
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lifeskim:mentions |
umls-concept:C0015811,
umls-concept:C0205263,
umls-concept:C0302600,
umls-concept:C0331858,
umls-concept:C0871261,
umls-concept:C1515655,
umls-concept:C1704632,
umls-concept:C1704640,
umls-concept:C1706515,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
2005-7-13
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pubmed:abstractText |
We investigated the angiogenic response induced by acellular femoral matrices implanted in vivo on to the chick embryo chorioallantoic membrane (CAM), a useful model for such investigation. The results showed that acellular matrices were able to induce a strong angiogenic response, comparable with that of fibroblast growth factor-2 (FGF-2), a well-known angiogenic cytokine. The angiogenic response was further increased when exogenous FGF-2 or transforming growth factor beta-1 (TGF-beta1) was added to the matrices and inhibited by the addition of anti-FGF-2 or anti-TGF-beta1 antibodies. The response may be considered to be dependent on a direct angiogenic effect exerted by the matrices, and also in part by the presence of FGF-2 and TGF-beta1 in the acellular matrices.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16011546-10694891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16011546-11082362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16011546-11156103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16011546-11745087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16011546-12031118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16011546-1207385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16011546-12440590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16011546-14519506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16011546-1696268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16011546-2351696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16011546-2838270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16011546-7601314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16011546-7646187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16011546-7867582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16011546-8756760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16011546-9383707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16011546-9425998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16011546-9626625
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-8782
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
207
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79-83
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16011546-Angiogenesis Inducing Agents,
pubmed-meshheading:16011546-Animals,
pubmed-meshheading:16011546-Antibodies, Monoclonal,
pubmed-meshheading:16011546-Chick Embryo,
pubmed-meshheading:16011546-Chorioallantoic Membrane,
pubmed-meshheading:16011546-Extracellular Matrix,
pubmed-meshheading:16011546-Femur,
pubmed-meshheading:16011546-Fibroblast Growth Factor 2,
pubmed-meshheading:16011546-Immunohistochemistry,
pubmed-meshheading:16011546-Neovascularization, Physiologic,
pubmed-meshheading:16011546-Rats,
pubmed-meshheading:16011546-Tissue Culture Techniques,
pubmed-meshheading:16011546-Transforming Growth Factor beta,
pubmed-meshheading:16011546-Transforming Growth Factor beta1
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pubmed:year |
2005
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pubmed:articleTitle |
Angiogenic response induced by acellular femoral matrix in vivo.
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pubmed:affiliation |
Department of Pharmaceutical Sciences, University of Padua, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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