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rdf:type |
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lifeskim:mentions |
umls-concept:C0004096,
umls-concept:C0021758,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0332307,
umls-concept:C0442805,
umls-concept:C0547040,
umls-concept:C1327413,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:dateCreated |
2005-9-5
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pubmed:abstractText |
Virus infections are the major cause of asthma exacerbations. CD8+ T cells have an important role in antiviral immune responses and animal studies suggest a role for CD8+ T cells in the pathogenesis of virus-induced asthma exacerbations. We have previously shown that the presence of IL-4 during stimulation increases the frequency of IL-5-positive cells and CD30 surface staining in CD8+ T cells from healthy, normal subjects. In this study, we investigated whether excess IL-4 during repeated TCR/CD3 stimulation of CD8+ T cells from atopic asthmatic subjects alters the balance of type 1/type 2 cytokine production in favour of the latter.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-10725199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-10873302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-11112143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-11222503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-11852895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-11897281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-11923159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-11923551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-11991881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-12773328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-12900275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-14610471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-1530827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-3497196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-7511681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-7767192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-7869040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-7881686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-7921434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-7963550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-8241910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-8576572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-8764032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-8934830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-9036953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-9314350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-9343225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16001979-9923875
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-993X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16001979-Adult,
pubmed-meshheading:16001979-Asthma,
pubmed-meshheading:16001979-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16001979-Cells, Cultured,
pubmed-meshheading:16001979-Female,
pubmed-meshheading:16001979-Humans,
pubmed-meshheading:16001979-Integrin alpha4beta1,
pubmed-meshheading:16001979-Interleukin-13,
pubmed-meshheading:16001979-Interleukin-4,
pubmed-meshheading:16001979-Interleukin-5,
pubmed-meshheading:16001979-Lymphocyte Activation,
pubmed-meshheading:16001979-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:16001979-Male,
pubmed-meshheading:16001979-Middle Aged,
pubmed-meshheading:16001979-Th1 Cells,
pubmed-meshheading:16001979-Th2 Cells
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pubmed:year |
2005
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pubmed:articleTitle |
IL-4 increases type 2, but not type 1, cytokine production in CD8+ T cells from mild atopic asthmatics.
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pubmed:affiliation |
Department of Respiratory Medicine, National Heart and Lung Institute, Wright Fleming Institute for Infection and Immunity, Imperial College London, Norfolk Place, London, UK. l.stanciu@imperial.ac.uk
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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