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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
27
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pubmed:dateCreated |
2005-7-7
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pubmed:abstractText |
We established the importance of phosphorylation of cAMP responsive element-binding protein (CREB) to both the familiarity discrimination component of long-term recognition memory and plasticity within the perirhinal cortex of the temporal lobe. Adenoviral transduction of perirhinal cortex (and adjacent visual association cortex) with a dominant-negative inhibitor of CREB impaired the preferential exploration of novel over familiar objects at a long (24 h) but not a short (15 min) delay, disrupted the normal reduced activation of perirhinal neurons to familiar compared with novel pictures, and impaired long-term potentiation of synaptic transmission in perirhinal slices. The consistency of these effects across the behavioral, systems, and cellular levels of analysis provides strong evidence for involvement of CREB phosphorylation in synaptic plastic processes within perirhinal cortex necessary for long-term recognition memory.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1529-2401
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pubmed:author |
pubmed-author:AggletonJohn PJP,
pubmed-author:BashirZafar IZI,
pubmed-author:BienemannAlisonA,
pubmed-author:BrownMalcolm WMW,
pubmed-author:DeuschleUleU,
pubmed-author:GloverColin P JCP,
pubmed-author:JohnsonBenB,
pubmed-author:KewJames N CJN,
pubmed-author:MasseyPeter VPV,
pubmed-author:UneyJamesJ,
pubmed-author:WanHuminH,
pubmed-author:WarburtonE CleaEC
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pubmed:issnType |
Electronic
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pubmed:day |
6
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6296-303
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pubmed:dateRevised |
2008-12-3
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pubmed:meshHeading |
pubmed-meshheading:16000619-Adenoviridae,
pubmed-meshheading:16000619-Animals,
pubmed-meshheading:16000619-Association Learning,
pubmed-meshheading:16000619-Cyclic AMP,
pubmed-meshheading:16000619-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:16000619-Defective Viruses,
pubmed-meshheading:16000619-Discrimination (Psychology),
pubmed-meshheading:16000619-Discrimination Learning,
pubmed-meshheading:16000619-Entorhinal Cortex,
pubmed-meshheading:16000619-Excitatory Postsynaptic Potentials,
pubmed-meshheading:16000619-Exploratory Behavior,
pubmed-meshheading:16000619-Genes, Reporter,
pubmed-meshheading:16000619-Genes, fos,
pubmed-meshheading:16000619-Genetic Vectors,
pubmed-meshheading:16000619-Green Fluorescent Proteins,
pubmed-meshheading:16000619-Long-Term Potentiation,
pubmed-meshheading:16000619-Male,
pubmed-meshheading:16000619-Pattern Recognition, Visual,
pubmed-meshheading:16000619-Phosphorylation,
pubmed-meshheading:16000619-Photic Stimulation,
pubmed-meshheading:16000619-Protein Processing, Post-Translational,
pubmed-meshheading:16000619-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:16000619-Rats,
pubmed-meshheading:16000619-Recombinant Fusion Proteins,
pubmed-meshheading:16000619-Single-Blind Method,
pubmed-meshheading:16000619-Synaptic Transmission,
pubmed-meshheading:16000619-Temporal Lobe,
pubmed-meshheading:16000619-Transcription, Genetic,
pubmed-meshheading:16000619-Transduction, Genetic
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pubmed:year |
2005
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pubmed:articleTitle |
cAMP responsive element-binding protein phosphorylation is necessary for perirhinal long-term potentiation and recognition memory.
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pubmed:affiliation |
Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1 TD, United Kingdom.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
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