Source:http://linkedlifedata.com/resource/pubmed/id/15998373
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
2005-7-6
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pubmed:abstractText |
The authors have recently defined the clinopathological entity of a mucin-producing bile duct tumor (MPBT), and divided MPBT into two distinct subtypes: 'columnar-type' and 'cuboidal-type' MPBT. Mucin core protein 6 (MUC6), which is present in normal pyloric glands, had higher expression levels in cuboidal-type tumors than in columnar-type tumors. In the pyloric glands, a carbohydrate antigen detected by monoclonal antibody HIK1083 (CA/HIK1083) is also expressed. In order to evaluate the coexpression pattern of MUC6 and CA/HIK1083 in MPBT, expression profiles were evaluated in 38 surgically excised mucin-producing bile duct carcinomas (MPBC; cuboidal-type, n = 15; columnar-type, n = 23), using immunohistochemistry. The staining rate was graded as follows: -, <5% of neoplastic cells stained; +, 5% to <20%; + +, 20% to <50%; + + +, > or =50%. In cuboidal-type MPBC, MUC6 was positive in all cases (+ + +, 13/15; + +, 1/15; +, 1/15), whereas CA/HIK1083 was negative in all cases (-, 15/15; P < 0.0001). In columnar-type MPBC, MUC6 was positive in 65% of cases (+ + +, 6/23; + +, 8/23; +, 1/23; -, 8/23), and CA/HIK1083 was positive in 52% (+ +, 3/23; +, 9/23; -, 11/23; not significant). Our results clearly demonstrate that cuboidal-type MPBC have an aberrant pyloric glandular phenotype, that is, MUC6+/CA/HIK1083-. This unique profile may be related to different outcomes of patients with MPBC.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Tumor-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Carbohydrates,
http://linkedlifedata.com/resource/pubmed/chemical/MUC6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mucin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Mucins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1320-5463
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
464-70
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15998373-Adenocarcinoma, Mucinous,
pubmed-meshheading:15998373-Adult,
pubmed-meshheading:15998373-Aged,
pubmed-meshheading:15998373-Aged, 80 and over,
pubmed-meshheading:15998373-Antibodies, Monoclonal,
pubmed-meshheading:15998373-Antigens, Tumor-Associated, Carbohydrate,
pubmed-meshheading:15998373-Bile Duct Neoplasms,
pubmed-meshheading:15998373-Bile Ducts, Extrahepatic,
pubmed-meshheading:15998373-Carbohydrates,
pubmed-meshheading:15998373-Female,
pubmed-meshheading:15998373-Gastric Mucosa,
pubmed-meshheading:15998373-Humans,
pubmed-meshheading:15998373-Immunohistochemistry,
pubmed-meshheading:15998373-Male,
pubmed-meshheading:15998373-Middle Aged,
pubmed-meshheading:15998373-Mucin-6,
pubmed-meshheading:15998373-Mucins,
pubmed-meshheading:15998373-Peptides
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pubmed:year |
2005
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pubmed:articleTitle |
Aberrant expression of pyloric gland-type mucin in mucin-producing bile duct carcinomas: a clear difference between the core peptide and the carbohydrate moiety.
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pubmed:affiliation |
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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