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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-8-1
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pubmed:abstractText |
We evaluated the role of D-amino-acid oxidase on spatial learning and long-term potentiation (LTP) in the hippocampus, since this enzyme metabolizes D-amino-acids, some of which enhance the N-methyl-D-aspartate receptor functions. The Morris water maze learning and the LTP in the CA1 area of the hippocampal slice were observed in wild-type mice and mutant mice lacking D-amino-acid oxidase. The mutant mice showed significantly shorter platform search times in the water maze and significantly larger hippocampal LTPs than the wild-type mice. These results suggest that the abundant D-amino-acids in the mutant mouse brain facilitate hippocampal LTP and spatial learning.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0168-0102
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
34-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15996778-6-Cyano-7-nitroquinoxaline-2,3-dione,
pubmed-meshheading:15996778-Analysis of Variance,
pubmed-meshheading:15996778-Animals,
pubmed-meshheading:15996778-Behavior, Animal,
pubmed-meshheading:15996778-D-Amino-Acid Oxidase,
pubmed-meshheading:15996778-Electric Stimulation,
pubmed-meshheading:15996778-Excitatory Amino Acid Antagonists,
pubmed-meshheading:15996778-Excitatory Postsynaptic Potentials,
pubmed-meshheading:15996778-Hippocampus,
pubmed-meshheading:15996778-Learning,
pubmed-meshheading:15996778-Long-Term Potentiation,
pubmed-meshheading:15996778-Male,
pubmed-meshheading:15996778-Maze Learning,
pubmed-meshheading:15996778-Membrane Potentials,
pubmed-meshheading:15996778-Mice,
pubmed-meshheading:15996778-Mice, Knockout,
pubmed-meshheading:15996778-Patch-Clamp Techniques,
pubmed-meshheading:15996778-Pyramidal Cells,
pubmed-meshheading:15996778-Spatial Behavior,
pubmed-meshheading:15996778-Swimming
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pubmed:year |
2005
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pubmed:articleTitle |
Spatial learning and long-term potentiation of mutant mice lacking D-amino-acid oxidase.
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pubmed:affiliation |
Department of Physiology and Biological Information, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan. maekawa@dokkyomed.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
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