Linked Life Data

15992745

Source:http://linkedlifedata.com/resource/pubmed/id/15992745

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2005-7-4
pubmed:abstractText
In many apoptotic responses, pro-apoptotic members of the Bcl-2 family trigger the permeabilization of the outer mitochondrial membrane, thereby allowing the release of mitochondrial apoptogenic factors that contribute to caspase activation in the cytosol. The mechanisms that lead to the activation of pro-apoptotic Bcl-2 family members and to the permeabilization of the outer mitochondrial membrane are not yet completely understood. Here, we attempt to summarize our current view of the mechanisms that lead to these events, regarding both additional proteins that were recently suggested to be involved, and the roles of lipids.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1631-0691
pubmed:author
pubmed:issnType
Print
pubmed:volume
328
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
616-31
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Regulation of Bcl-2 proteins and of the permeability of the outer mitochondrial membrane.
pubmed:affiliation
Department of Cell Biology, University of Geneva, 30, quai Ernest-Ansermet, 1211 Genève 4, Switzerland.
pubmed:publicationType
Journal Article, Review