Source:http://linkedlifedata.com/resource/pubmed/id/15979781
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2005-9-13
|
| pubmed:abstractText |
To clarify the modifying effect of the codon 72 p53 polymorphism on hepatocellular carcinoma (HCC) stratified by chronic hepatitis B virus (HBV) infection status, 111 incident cases of HCC and 424 controls in HBV-negative subjects and 135 cases and 125 controls in HBV-positive subjects were identified. No correlation between the polymorphism and HCC risk was found when comparing the HBV-positive cases to controls. However, in HBV-negative subjects, Arg/Pro and Pro/Pro genotypes had a 1.97-fold and a 3.36-fold increased risk for HCC, respectively. In subjects with the Pro allele and family history of HCC yielded an 11.81-fold increased risk of HCC.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0304-3835
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
8
|
| pubmed:volume |
229
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
77-83
|
| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15979781-Adult,
pubmed-meshheading:15979781-Aged,
pubmed-meshheading:15979781-Carcinoma, Hepatocellular,
pubmed-meshheading:15979781-Case-Control Studies,
pubmed-meshheading:15979781-Codon,
pubmed-meshheading:15979781-Female,
pubmed-meshheading:15979781-Genes, p53,
pubmed-meshheading:15979781-Genetic Predisposition to Disease,
pubmed-meshheading:15979781-Genotype,
pubmed-meshheading:15979781-Hepatitis B, Chronic,
pubmed-meshheading:15979781-Humans,
pubmed-meshheading:15979781-Liver Neoplasms,
pubmed-meshheading:15979781-Male,
pubmed-meshheading:15979781-Middle Aged,
pubmed-meshheading:15979781-Polymerase Chain Reaction,
pubmed-meshheading:15979781-Polymorphism, Genetic,
pubmed-meshheading:15979781-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:15979781-Risk Factors
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
A p53 polymorphism modifies the risk of hepatocellular carcinoma among non-carriers but not carriers of chronic hepatitis B virus infection.
|
| pubmed:affiliation |
Department of Pathology, Eastern Hepatobiliary Surgery Hospital, No. 225 Changhai Road, 200438 Shanghai, People's Republic of China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|