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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-7-21
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pubmed:abstractText |
In Xenopus laevis, amputation of the adult limb results in the formation of a simple (hypomorphic) spike-like structure without joints, although tadpole limb bud regenerates complete limb pattern. The expression of some joint marker genes was examined in limb development and regeneration. Bmp-4 and gdf-5 were expressed and sox-9 expression was decreased in the joint region. Although developing cartilages were well-organized and had bmp-4 expressing perichondrocytes, the spike cartilage did not have such a structure, but only showed sparse bmp-4 expression. Application of BMP4-soaked beads to the spike led to the induction of a joint-like structure. These results suggest that the lack of joints in the spike is due to the deficiency of the accumulation of the cells that express bmp-4. Improvement of regeneration in the Xenopus adult limb that we report here for the first time will give us important insights into epimorphic regeneration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 4,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cibacron Blue F 3GA,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Differentiation Factor 5,
http://linkedlifedata.com/resource/pubmed/chemical/High Mobility Group Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Molecular Probes,
http://linkedlifedata.com/resource/pubmed/chemical/SOX9 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Triazines,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/bmp4 protein, Xenopus
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1058-8388
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2005 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
233
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1444-53
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15977182-Animals,
pubmed-meshheading:15977182-Bone Morphogenetic Protein 4,
pubmed-meshheading:15977182-Bone Morphogenetic Proteins,
pubmed-meshheading:15977182-Cartilage,
pubmed-meshheading:15977182-Extremities,
pubmed-meshheading:15977182-Growth Differentiation Factor 5,
pubmed-meshheading:15977182-High Mobility Group Proteins,
pubmed-meshheading:15977182-Immunohistochemistry,
pubmed-meshheading:15977182-Joints,
pubmed-meshheading:15977182-Molecular Probes,
pubmed-meshheading:15977182-Regeneration,
pubmed-meshheading:15977182-SOX9 Transcription Factor,
pubmed-meshheading:15977182-Transcription Factors,
pubmed-meshheading:15977182-Triazines,
pubmed-meshheading:15977182-Xenopus Proteins,
pubmed-meshheading:15977182-Xenopus laevis
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pubmed:year |
2005
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pubmed:articleTitle |
Joint development in Xenopus laevis and induction of segmentations in regenerating froglet limb (spike).
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pubmed:affiliation |
Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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