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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2005-7-4
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pubmed:abstractText |
The small intestine is constructed of many crypts and villi, and mouse studies suggest that each crypt contains multiple stem cells. Very little is known about human small intestines because mouse fate mapping strategies are impractical in humans. However, it is theoretically possible that stem cell histories are inherently written within their genomes. Genomes appear to record histories (as exemplified by use of molecular clocks), and therefore it may be possible to reconstruct somatic cell dynamics from somatic cell errors. Recent human colon studies suggest that random somatic epigenetic errors record stem cell histories (ancestry and total numbers of divisions). Potentially age-related methylation also occurs in human small intestines, which would allow characterization of their stem cells and comparisons with the colon.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-10802941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-11517339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-11553798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-11689954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-11782440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-11782954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-12683973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-12814429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-1316306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-1350108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-1415475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-14731078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-15039224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-2100251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-5939338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-7028576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-8944567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-9087208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-9295317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15975143-9850084
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
1741-7015
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15975143-Adolescent,
pubmed-meshheading:15975143-Adult,
pubmed-meshheading:15975143-Age Factors,
pubmed-meshheading:15975143-Aged,
pubmed-meshheading:15975143-Cell Lineage,
pubmed-meshheading:15975143-DNA Methylation,
pubmed-meshheading:15975143-Epigenesis, Genetic,
pubmed-meshheading:15975143-Humans,
pubmed-meshheading:15975143-Intestine, Small,
pubmed-meshheading:15975143-Middle Aged,
pubmed-meshheading:15975143-Stem Cells
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pubmed:year |
2005
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pubmed:articleTitle |
Age-related human small intestine methylation: evidence for stem cell niches.
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pubmed:affiliation |
Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA. jungyeok@usc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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