Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2005-6-21
pubmed:abstractText
Fatty liver at ultrasounds, with/ without raised plasma levels of hepatic enzymes, is common in obesity. In most cases, it is the hallmark of non-alcoholic fatty liver disease (NAFLD), a potentially progressive disease associated with insulin resistance and the metabolic syndrome (MS). We tested the hypothesis that insulin resistance per se might be associated with hepatocellular necrosis. Alanine and aspartate aminotransferases (ALT and AST; no.=799) and gamma-glutamyltranspeptidase (GGT; no.=459) were analyzed in a group of treatment-seeking obese patients recruited in 12 Italian medical centers. Insulin resistance was calculated by the homeostasis model assessment method (HOMA-IR; no.=522). Median ALT and AST increased with increasing obesity class (p=0.001 and p=0.005) and exceeded normal limits in 21.0% of cases. Also HOMA-IR increased with the obesity class (p<0.0001), and was higher in subjects with elevated ALT (median, 4.93 vs 2.89; p<0.0001). A significant correlation was observed between HOMA-IR and ALT (R2=0.208; p<0.0001), as well as between HOMA-IR and AST or GGT (R2=0.112 and R2=0.080; p<0.0001). The correlation was maintained when cases with elevated enzyme levels were omitted from analysis. Diabetes and hypertriglyceridemia were the features of the MS most commonly associated with raised liver enzymes. In logistic regression, after correction for age, gender, BMI and features of the MS, HOMA-IR maintained a highly predictive value for raised ALT, AST and GGT. We conclude that in obesity insulin resistance is a risk factor for raised liver enzyme levels, possibly related to NAFLD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0391-4097
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
333-9
pubmed:meshHeading
pubmed-meshheading:15966506-Adult, pubmed-meshheading:15966506-Aged, pubmed-meshheading:15966506-Alanine Transaminase, pubmed-meshheading:15966506-Aspartate Aminotransferases, pubmed-meshheading:15966506-Cross-Sectional Studies, pubmed-meshheading:15966506-Disease Progression, pubmed-meshheading:15966506-Fatty Liver, pubmed-meshheading:15966506-Female, pubmed-meshheading:15966506-Humans, pubmed-meshheading:15966506-Insulin Resistance, pubmed-meshheading:15966506-Liver, pubmed-meshheading:15966506-Male, pubmed-meshheading:15966506-Metabolic Syndrome X, pubmed-meshheading:15966506-Middle Aged, pubmed-meshheading:15966506-Necrosis, pubmed-meshheading:15966506-Obesity, pubmed-meshheading:15966506-Regression Analysis, pubmed-meshheading:15966506-Risk Factors, pubmed-meshheading:15966506-gamma-Glutamyltransferase
pubmed:year
2005
pubmed:articleTitle
Aminotransferase and gamma-glutamyltranspeptidase levels in obesity are associated with insulin resistance and the metabolic syndrome.
pubmed:affiliation
Metabolic Unit, Department of Internal Medicine and Gastroenterology, Alma Mater Studiorum University of Bologna, Bologna, Italy. giulio.marchesini@unibo.it
pubmed:publicationType
Journal Article, Multicenter Study