| pubmed-article:15963786 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15963786 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:15963786 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:15963786 | lifeskim:mentions | umls-concept:C1336789 | lld:lifeskim |
| pubmed-article:15963786 | lifeskim:mentions | umls-concept:C1415044 | lld:lifeskim |
| pubmed-article:15963786 | lifeskim:mentions | umls-concept:C0815089 | lld:lifeskim |
| pubmed-article:15963786 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:15963786 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15963786 | pubmed:dateCreated | 2005-6-20 | lld:pubmed |
| pubmed-article:15963786 | pubmed:abstractText | The mechanisms controlling the differentiation of dendritic cells (DCs) remain largely unknown. Using a transcriptional profiling approach, we identified Gfi1 as a novel critical transcription factor in DC differentiation. Gfi1-/- mice showed a global reduction of myeloid and lymphoid DCs in all lymphoid organs whereas epidermal Langerhans cells were enhanced in number. In vivo, Gfi1-/- DCs showed striking phenotypic and functional alterations such as defective maturation and increased cytokine production. In vitro, Gfi1-/- hematopoietic progenitor cells were unable to develop into DCs. Instead, they differentiated into macrophages, suggesting that Gfi1 is a critical modulator of DC versus macrophage development. Analysis of hematopoietic chimeras and retrovirus-reconstituted hematopoietic progenitor cells established a cell autonomous and nonredundant role for Gfi1 in DC development. The developmental defect of Gfi1-/- progenitor cells was associated with decreased STAT3 activation. In conclusion, we have identified Gfi1 as a critical transcription factor that controls DC versus macrophage development and dissociates DC maturation and activation. | lld:pubmed |
| pubmed-article:15963786 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15963786 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15963786 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15963786 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15963786 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15963786 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:15963786 | pubmed:author | pubmed-author:KleinChristop... | lld:pubmed |
| pubmed-article:15963786 | pubmed:author | pubmed-author:MöröyTarikT | lld:pubmed |
| pubmed-article:15963786 | pubmed:author | pubmed-author:WelteKarlK | lld:pubmed |
| pubmed-article:15963786 | pubmed:author | pubmed-author:BuerJanJ | lld:pubmed |
| pubmed-article:15963786 | pubmed:author | pubmed-author:YücelRaifR | lld:pubmed |
| pubmed-article:15963786 | pubmed:author | pubmed-author:GeffersRobert... | lld:pubmed |
| pubmed-article:15963786 | pubmed:author | pubmed-author:ChozhavendanR... | lld:pubmed |
| pubmed-article:15963786 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15963786 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:15963786 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15963786 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15963786 | pubmed:pagination | 717-28 | lld:pubmed |
| pubmed-article:15963786 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15963786 | pubmed:meshHeading | pubmed-meshheading:15963786... | lld:pubmed |
| pubmed-article:15963786 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15963786 | pubmed:articleTitle | The transcriptional repressor Gfi1 controls STAT3-dependent dendritic cell development and function. | lld:pubmed |
| pubmed-article:15963786 | pubmed:affiliation | Department of Pediatric Hematology/Oncology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany. | lld:pubmed |
| pubmed-article:15963786 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15963786 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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