Source:http://linkedlifedata.com/resource/pubmed/id/15961511
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2005-9-20
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| pubmed:abstractText |
Heterozygous carriers of factor V (FV) Leiden who also carry FV deficiency often develop venous thromboembolism, but the thrombosis risk associated with this rare condition (pseudohomozygous activated protein C resistance) is still unclear. The thrombosis risk of genetically characterized pseudohomozygotes (n = 6) was compared with that of FV Leiden heterozygotes (n = 683) and homozygotes (n = 50) recruited within a large cohort study on familial thrombophilia. Both thrombin generation and Kaplan-Meier thrombosis-free survival analyses were performed in different FV genotype groups. FV Leiden pseudohomozygotes showed significantly higher thrombosis risk than heterozygotes. The thrombin generation test in pseudohomozygotes showed a pattern similar to homozygotes. Accordingly, early thrombotic manifestations occurred in pseudohomozygotes at a similar rate as in homozygotes. Thus, failure to recognize FV deficiency in FV Leiden heterozygotes may result in an underestimate of the thrombosis risk and inadequate management of affected patients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0006-4971
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
106
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2363-5
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15961511-Activated Protein C Resistance,
pubmed-meshheading:15961511-Adult,
pubmed-meshheading:15961511-Age Factors,
pubmed-meshheading:15961511-Aged,
pubmed-meshheading:15961511-Aged, 80 and over,
pubmed-meshheading:15961511-Anticoagulants,
pubmed-meshheading:15961511-Cohort Studies,
pubmed-meshheading:15961511-Disease-Free Survival,
pubmed-meshheading:15961511-Factor V,
pubmed-meshheading:15961511-Factor V Deficiency,
pubmed-meshheading:15961511-Genetic Predisposition to Disease,
pubmed-meshheading:15961511-Genotype,
pubmed-meshheading:15961511-Heterozygote,
pubmed-meshheading:15961511-Homozygote,
pubmed-meshheading:15961511-Humans,
pubmed-meshheading:15961511-Middle Aged,
pubmed-meshheading:15961511-Mutation,
pubmed-meshheading:15961511-Protein C,
pubmed-meshheading:15961511-Risk,
pubmed-meshheading:15961511-Thromboembolism,
pubmed-meshheading:15961511-Thrombosis,
pubmed-meshheading:15961511-Venous Thrombosis
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
An underestimated combination of opposites resulting in enhanced thrombotic tendency.
|
| pubmed:affiliation |
Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University of Padua Medical School, Padua, Italy. paolo.simioni@unipd.it
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|