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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-6-15
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pubmed:abstractText |
1. The pressor action of noradrenaline and its blockade by selective alpha(1)-adrenoceptor antagonists in the pithed mouse were evaluated. 2. Chloroethylclonidine (alpha(1B/D)-adrenoceptor alkylating agent) or BMY 7378 (alpha(1D)-adrenoceptor antagonist), both at 1 mg kg(-1), did not block the increase in blood pressure induced by noradrenaline. 3. 5-Methylurapidil (alpha(1A)-adrenoceptor antagonist), at 0.1 mg kg(-1), displaced the dose-response curve approximately six-fold to the right. 4. The results support the idea that the pithed mouse vasculature express alpha(1A)-adrenoceptors and suggest that it is a good model to study the roles of alpha(1)-adrenoceptors in gene knockout or overexpression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5-methylurapidil,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-1 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/BMY 7378,
http://linkedlifedata.com/resource/pubmed/chemical/Clonidine,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-1,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents,
http://linkedlifedata.com/resource/pubmed/chemical/chlorethylclonidine
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1474-8665
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
101-3
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15955029-Adrenergic alpha-1 Receptor Antagonists,
pubmed-meshheading:15955029-Adrenergic alpha-Antagonists,
pubmed-meshheading:15955029-Animals,
pubmed-meshheading:15955029-Blood Pressure,
pubmed-meshheading:15955029-Carotid Arteries,
pubmed-meshheading:15955029-Clonidine,
pubmed-meshheading:15955029-Decerebrate State,
pubmed-meshheading:15955029-Dose-Response Relationship, Drug,
pubmed-meshheading:15955029-Drug Synergism,
pubmed-meshheading:15955029-Heart Rate,
pubmed-meshheading:15955029-Male,
pubmed-meshheading:15955029-Mice,
pubmed-meshheading:15955029-Models, Animal,
pubmed-meshheading:15955029-Norepinephrine,
pubmed-meshheading:15955029-Piperazines,
pubmed-meshheading:15955029-Receptors, Adrenergic, alpha-1,
pubmed-meshheading:15955029-Vagotomy,
pubmed-meshheading:15955029-Vasoconstrictor Agents
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pubmed:year |
2005
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pubmed:articleTitle |
Postjunctional alpha1-adrenoceptors in the vasculature of the pithed mouse are of the alpha1A-subtype.
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pubmed:affiliation |
Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados, Sede Sur, México D.F.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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