Source:http://linkedlifedata.com/resource/pubmed/id/15944298
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2005-6-9
|
| pubmed:abstractText |
Immunity to the opportunistic fungus Cryptococcus neoformans is dependent on cell-mediated immunity. Individuals with defects in cellular immunity, CD4(+) T cells in particular, are susceptible to infection with this pathogen. In host defense against a number of pathogens, CD8(+) T cell responses are dependent upon CD4(+) T cell help. The goal of these studies was to determine whether CD4(+) T cells are required for the generation of antifungal CD8(+) T cell effectors during pulmonary C. neoformans infection. Using a murine intratracheal infection model, our results demonstrated that CD4(+) T cells were not required for the expansion and trafficking of CD8(+) T cells to the site of infection. CD4(+) T cells were also not required for the generation of IFN-gamma-producing CD8(+) T cell effectors in the lungs. In CD4(-) mice, depletion of CD8(+) T cells resulted in increased intracellular infection of pulmonary macrophages by C. neoformans, increasing the pulmonary burden of the infection. Neutralization of IFN-gamma in CD4(-)CD8(+) mice similarly increased macrophage infection by C. neoformans, thereby blocking the protection provided by CD8(+) T cells. Altogether, these data support the hypothesis that effector CD8(+) T cell function is independent of CD4(+) T cells and that IFN-gamma production from CD8(+) T cells plays a role in controlling C. neoformans by limiting survival of C. neoformans within macrophages.
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| pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/R01-AI049448,
http://linkedlifedata.com/resource/pubmed/grant/R01-AI059201,
http://linkedlifedata.com/resource/pubmed/grant/R01-HL051082,
http://linkedlifedata.com/resource/pubmed/grant/R01-HL065912,
http://linkedlifedata.com/resource/pubmed/grant/T32-AI07413
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
174
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
7920-8
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| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:15944298-Animals,
pubmed-meshheading:15944298-Antibodies, Monoclonal,
pubmed-meshheading:15944298-CD4-Positive T-Lymphocytes,
pubmed-meshheading:15944298-CD8-Positive T-Lymphocytes,
pubmed-meshheading:15944298-Cell Differentiation,
pubmed-meshheading:15944298-Cell Movement,
pubmed-meshheading:15944298-Cell Proliferation,
pubmed-meshheading:15944298-Cryptococcosis,
pubmed-meshheading:15944298-Cryptococcus neoformans,
pubmed-meshheading:15944298-Female,
pubmed-meshheading:15944298-Interferon-gamma,
pubmed-meshheading:15944298-Intracellular Fluid,
pubmed-meshheading:15944298-Lung,
pubmed-meshheading:15944298-Lymph Nodes,
pubmed-meshheading:15944298-Lymphocyte Activation,
pubmed-meshheading:15944298-Lymphocyte Depletion,
pubmed-meshheading:15944298-Lymphopenia,
pubmed-meshheading:15944298-Macrophages, Alveolar,
pubmed-meshheading:15944298-Mice,
pubmed-meshheading:15944298-Mice, Inbred CBA
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| pubmed:year |
2005
|
| pubmed:articleTitle |
Generation of antifungal effector CD8+ T cells in the absence of CD4+ T cells during Cryptococcus neoformans infection.
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| pubmed:affiliation |
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
|