Linked Life Data

15936505

Source:http://linkedlifedata.com/resource/pubmed/id/15936505

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2005-6-6
pubmed:abstractText
In this study we aimed to evaluate the possibility of using cerebrospinal fluid (CSF) tau, Abeta(1-42) and inflammatory cytokines for diagnosis of Alzheimer's disease (AD) and vascular dementia (VD). We measured levels of total tau (T-tau), phospho-tau (P-tau), Abeta(1-42), IL-6, and TNFalpha in CSF in groups of AD, VD, and controls using enzyme-linked immunosorbent assay (ELISA). T-tau level was found significantly higher in groups of AD (t = 3.015, P < 0.01) and VD (t = 2.872, P < 0.01) than in controls. IL-6 level as also higher in AD (t = 2.883, P < 0.01) and VD (t = 3.032, P < 0.01) than in controls. Both T-tau and IL-6 were not significantly different between AD and VD (P > 0.05). The group of AD had remarkably higher P-tau (t = 4.261 and 3.883, respectively, P < 0.01) and lower Abeta(1-42) (t = 3.883 and 4.129, respectively, P < 0.01), as compared with those in VD and controls. TNFalpha level in AD was significantly higher than that in controls (t = 2.745, P < 0.01), but lower than in VD (t = 3.032, P < 0.01). Our data suggested that increment of T-tau and IL-6 levels in CSF was useful for screening AD and VD in certain population, while descending Abeta(1-42) and ascending TNFalpha in CSF are preferable to diagnose AD. In addition, a higher level of CSF P-tau might support AD diagnosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:volume
383
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
12-6
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:articleTitle
Cerebrospinal fluid tau, Abeta1-42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia.
pubmed:affiliation
Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing, China. jjpneuro@public3.bta.net.cn
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't