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pubmed-article:15927063pubmed:abstractTextThe burden of proteinases from inflammatory cells in the lung of subjects with type Pi ZZ of alpha-1-antitrypsin deficiency is higher than in those without the deficiency. Cross-sectional studies have shown increased levels of biomarkers of extracellular matrix degradation in vivo. Longitudinal variability of these biomarkers is unknown but desirable for clinical studies with proteinase inhibitors.lld:pubmed
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pubmed-article:15927063pubmed:articleTitleShort-term variability of biomarkers of proteinase activity in patients with emphysema associated with type Z alpha-1-antitrypsin deficiency.lld:pubmed
pubmed-article:15927063pubmed:affiliationDepartment of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands. j.stolk.long@lumc.nllld:pubmed
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