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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2005-6-27
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pubmed:abstractText |
The burden of proteinases from inflammatory cells in the lung of subjects with type Pi ZZ of alpha-1-antitrypsin deficiency is higher than in those without the deficiency. Cross-sectional studies have shown increased levels of biomarkers of extracellular matrix degradation in vivo. Longitudinal variability of these biomarkers is unknown but desirable for clinical studies with proteinase inhibitors.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-10556107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-10885422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-11112116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-12034572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-12114340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-12324680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-12412702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-12714341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-14563926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-14582923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-14764080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-14981697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-1554198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-15618590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-2440636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-3257661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-3525610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-3890638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-474517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-7697272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-7763294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-8887591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927063-9061309
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-993X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
47
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15927063-Adult,
pubmed-meshheading:15927063-Biological Markers,
pubmed-meshheading:15927063-Desmosine,
pubmed-meshheading:15927063-Double-Blind Method,
pubmed-meshheading:15927063-Emphysema,
pubmed-meshheading:15927063-Female,
pubmed-meshheading:15927063-Heparitin Sulfate,
pubmed-meshheading:15927063-Humans,
pubmed-meshheading:15927063-Hyaluronic Acid,
pubmed-meshheading:15927063-Male,
pubmed-meshheading:15927063-Peptide Hydrolases,
pubmed-meshheading:15927063-Placebo Effect,
pubmed-meshheading:15927063-Reproducibility of Results,
pubmed-meshheading:15927063-Sensitivity and Specificity,
pubmed-meshheading:15927063-Treatment Outcome,
pubmed-meshheading:15927063-alpha 1-Antitrypsin Deficiency
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pubmed:year |
2005
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pubmed:articleTitle |
Short-term variability of biomarkers of proteinase activity in patients with emphysema associated with type Z alpha-1-antitrypsin deficiency.
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pubmed:affiliation |
Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands. j.stolk.long@lumc.nl
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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