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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7-8
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pubmed:dateCreated |
2005-7-25
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pubmed:abstractText |
The synthetic immunomodulator cytotoxic T lymphocyte antigen 4-Ig (CTLA-4-Ig) initiates effects in human monocyte-derived dendritic cells (DC) that rely on immunosuppressive tryptophan catabolism. However, it is unable to induce suppressive properties in DC matured by CD40 engagement. Thus, CD40-driven events may physiologically set human DC free from restraint by regulatory cells expressing surface CTLA-4.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1286-4579
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1040-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15925532-Animals,
pubmed-meshheading:15925532-Antigens, CD40,
pubmed-meshheading:15925532-Cell Proliferation,
pubmed-meshheading:15925532-Dendritic Cells,
pubmed-meshheading:15925532-Female,
pubmed-meshheading:15925532-Humans,
pubmed-meshheading:15925532-Immune Tolerance,
pubmed-meshheading:15925532-Immunoconjugates,
pubmed-meshheading:15925532-Interferon-gamma,
pubmed-meshheading:15925532-Mice,
pubmed-meshheading:15925532-Mice, Inbred DBA,
pubmed-meshheading:15925532-Protein Binding,
pubmed-meshheading:15925532-Tryptophan,
pubmed-meshheading:15925532-Tryptophan Oxygenase,
pubmed-meshheading:15925532-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2005
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pubmed:articleTitle |
CD40 ligation prevents onset of tolerogenic properties in human dendritic cells treated with CTLA-4-Ig.
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pubmed:affiliation |
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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