Source:http://linkedlifedata.com/resource/pubmed/id/15925409
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2005-10-11
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pubmed:abstractText |
Botulinum toxins are metalloproteases that act inside nerve terminals and block neurotransmitter release via their activity directed specifically on SNARE proteins. This review summarizes data on botulinum toxin modes of binding, sites of action, and biochemical activities. Their use in cell biology and neuroscience is considered, as well as their therapeutic utilization in human diseases characterized by hyperfunction of cholinergic terminals.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0161-813X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
761-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15925409-Animals,
pubmed-meshheading:15925409-Autonomic Nervous System Diseases,
pubmed-meshheading:15925409-Botulinum Toxins,
pubmed-meshheading:15925409-Humans,
pubmed-meshheading:15925409-Neurons,
pubmed-meshheading:15925409-Neurotoxins,
pubmed-meshheading:15925409-Protein Binding,
pubmed-meshheading:15925409-SNARE Proteins,
pubmed-meshheading:15925409-Tetanus Toxin
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pubmed:year |
2005
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pubmed:articleTitle |
Internalization and mechanism of action of clostridial toxins in neurons.
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pubmed:affiliation |
Department of Medical Pharmacology and CNR Institute of Neuroscience, Center of Excellence for Neurodegenerative Diseases, University of Milano, Via Vanvitelli 32, 20129 Milano, Italy.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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