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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0023828,
umls-concept:C0205314,
umls-concept:C0567416,
umls-concept:C0679622,
umls-concept:C0699040,
umls-concept:C0871261,
umls-concept:C1145667,
umls-concept:C1335808,
umls-concept:C1533691,
umls-concept:C1611341,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
1-2
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pubmed:dateCreated |
2005-5-30
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pubmed:abstractText |
We previously reported that synthetic sulfo-glycolipid, 3-O-(6-deoxy-6-sulfono-beta-D-glucopyranosyl)-1,2-di-O-acylglycerol (beta-SQDG(18:0)) which was deduced from sulfonoquinovosyl-diacylglycerols of sea urchin possessed immunosuppressive effects, such as human mixed lymphocyte reaction (MLR) and skin allograft in rat, and that these effects were caused by contact inhibition between T-cells and antigen presenting cells (APCs). Here, we investigated the mechanism of these immunosuppressive effects on human MLR by beta-SQAG9 which had been newly synthesized from beta-SQDG(18:0) to improve structural stability in water solution. CD62L+ T-cells in peripheral blood predominantly respond to APCs, and beta-SQAG9 inhibited the response of CD62L+ T-cell subset in human allogeneic MLR. Surprisingly, it was demonstrated that beta-SQAG9 bound to L- and P-selectin (CD62L and P) molecule in vitro. Meanwhile, beta-SQAG9 efficiently formed liposome structure and bound to L-selectin on the cell surface of CD62L+ T-cell subset but might not be incorporated into the cells. Because the immunosuppressive effects of beta-SQAG9 disappeared when beta-SQAG9 liposome was changed to soluble form by detergent, the liposome structure of beta-SQAG9 was presumed to be essential for these effects. These findings suggested beta-SQAG9 to be a novel drug with a unique immunosuppressive action.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0008-8749
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pubmed:author |
pubmed-author:FujitaTatsuyaT,
pubmed-author:GasaShinseiS,
pubmed-author:ImaiAkihitoA,
pubmed-author:JimbowKowichiK,
pubmed-author:MatsumotoKenjiroK,
pubmed-author:MatsumotoYoshitakaY,
pubmed-author:OhtaKeisukeK,
pubmed-author:SaharaHiroekiH,
pubmed-author:SakaguchiKengoK,
pubmed-author:SatoNoriyukiN,
pubmed-author:SugawaraFumioF,
pubmed-author:TakahashiNobuakiN,
pubmed-author:TakenouchiMikaM,
pubmed-author:TamuraYasuakiY,
pubmed-author:YamamotoYoshiteruY
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pubmed:issnType |
Print
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pubmed:volume |
232
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
105-15
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15922721-Antigens, Surface,
pubmed-meshheading:15922721-Glycolipids,
pubmed-meshheading:15922721-HL-60 Cells,
pubmed-meshheading:15922721-Humans,
pubmed-meshheading:15922721-L-Selectin,
pubmed-meshheading:15922721-Leukocytes, Mononuclear,
pubmed-meshheading:15922721-Liposomes,
pubmed-meshheading:15922721-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:15922721-P-Selectin,
pubmed-meshheading:15922721-Protein Binding,
pubmed-meshheading:15922721-T-Lymphocytes
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pubmed:articleTitle |
Inhibition of CD62L+ T-cell response in vitro via a novel sulfo-glycolipid, beta-SQAG9 liposome that binds to CD62L molecule on the cell surface.
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pubmed:affiliation |
Division of Plastic Surgery, Sapporo Medical University School of Medicine, South 1 West 17, Chuo-ku, Sapporo 060-8556, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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