Source:http://linkedlifedata.com/resource/pubmed/id/15922711
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
2005-5-30
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pubmed:abstractText |
B-cell receptor (BCR) ligation induces proliferation and survival in mature B-cells but conversely, can lead to apoptosis in immature B-cells. We have previously shown that c-Rel, a member of the NF-kappaB transcription factor family, is essential for mature B-cell survival and proliferation via regulation of the anti-apoptotic molecule Bcl-X and cell cycle genes E2F3a and cyclin E. Here, we report that c-Rel-deficient mature B-cells are rendered sensitive to BCR-induced growth arrest and apoptosis in a manner that strongly resembles the phenotypic response of immature B-cells to BCR signaling. We further demonstrate that BCR-stimulated immature B-cells are defective in NF-kappaB activation, but that introduction of two downstream c-Rel target genes, Bcl-X and cyclin E, can restore survival and proliferation to these cells. Our studies therefore suggest that specific blockade of NF-kappaB activation may be responsible for the growth arrest and apoptosis of BCR-activated immature B-cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bcl2l1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin E,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, B-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-X Protein
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pubmed:status |
MEDLINE
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pubmed:issn |
0008-8749
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
232
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9-20
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15922711-Animals,
pubmed-meshheading:15922711-B-Lymphocytes,
pubmed-meshheading:15922711-Cell Proliferation,
pubmed-meshheading:15922711-Cell Survival,
pubmed-meshheading:15922711-Crosses, Genetic,
pubmed-meshheading:15922711-Cyclin E,
pubmed-meshheading:15922711-Gene Expression Regulation,
pubmed-meshheading:15922711-Genes, rel,
pubmed-meshheading:15922711-Mice,
pubmed-meshheading:15922711-Mice, Inbred C57BL,
pubmed-meshheading:15922711-Mice, Knockout,
pubmed-meshheading:15922711-Mice, Transgenic,
pubmed-meshheading:15922711-NF-kappa B,
pubmed-meshheading:15922711-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:15922711-Receptors, Antigen, B-Cell,
pubmed-meshheading:15922711-Signal Transduction,
pubmed-meshheading:15922711-bcl-X Protein
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pubmed:articleTitle |
NF-kappaB inducible genes BCL-X and cyclin E promote immature B-cell proliferation and survival.
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pubmed:affiliation |
Division of Immunology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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