Linked Life Data

15922452

Source:http://linkedlifedata.com/resource/pubmed/id/15922452

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2005-10-11
pubmed:abstractText
Metabolic stress associated to mitochondrial dysfunction has been put forward as an important factor causing degeneration of mesencephalic dopamine-containing neurons in Parkinson's disease (PD). Here we overview how these neurons react to acute hypoxia or hypoglycemia, that are conditions of energy deprivation causing a reduced production of ATP by mitochondria. These neurons, which show a tonic firing discharge under normal condition, undergo into membrane hyperpolarization during hypoxia or hypoglycemia that silence their spontaneous activity. We outline the cellular mechanisms causing membrane hyperpolarization and the accompanied disturbances of intracellular calcium and sodium homeostasis. A better understanding of the changes occurring during transient energy deprivation might contribute to understand the physiopathology of these neurons that derives from mitochondrial dysfunction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0161-813X
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
857-68
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Dopamine-containing neurons are silenced by energy deprivation: a defensive response or beginning of cell death?
pubmed:affiliation
Fondazione Santa Lucia IRCCS-Laboratorio di Neurologia Sperimentale, Via Ardeatina 306, Fondazione Santa Lucia IRCCS, 00179 Rome, Italy. e.guatteohsantalucia.it
pubmed:publicationType
Journal Article, Review