|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2005-6-13
|
|
pubmed:abstractText |
This study was undertaken to reveal the role of NAD(P)H oxidase in increased oxidative stress in islets of Type 2 diabetes. Immunostaining analysis showed that staining intensities of NAD(P)H oxidase components, gp91phox and p22phox, significantly increased in islets of animal models of Type 2 diabetes, OLETF rats (60 weeks of age) and db/db mice (14 weeks of age), compared with age-matched controls, respectively, correlating with increased levels of oxidative stress marker, 8-hydroxy-deoxyguanosine or 4-hydroxy-2-nonenal modified protein. In db/db mice, oral administration of angiotensin II Type 1 receptor antagonist valsartan (5 mg/kg) for 4 weeks significantly attenuated the increased expression of gp91phox and p22phox together with inhibition of oxidative stress and partially restored decreased insulin contents in islets. Angiotensin II-related increased expression of NAD(P)H oxidase may play an important role in increased oxidative stress in islets of Type 2 diabetes. This mechanism may be a novel therapeutic target for preventing beta-cell damage.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-hydroxy-2-nonenal,
http://linkedlifedata.com/resource/pubmed/chemical/8-hydroxy-2'-deoxyguanosine,
http://linkedlifedata.com/resource/pubmed/chemical/Aldehydes,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II Type 1 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensins,
http://linkedlifedata.com/resource/pubmed/chemical/CYBA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cybb protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyguanosine,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NADPH Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Valine,
http://linkedlifedata.com/resource/pubmed/chemical/valsartan
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0006-291X
|
|
pubmed:author |
pubmed-author:InoguchiToyoshiT,
pubmed-author:KobayashiKunihisaK,
pubmed-author:MaedaYasutakaY,
pubmed-author:NakayamaMiekoM,
pubmed-author:NawataHajimeH,
pubmed-author:SasakiShujiS,
pubmed-author:SawadaFumiF,
pubmed-author:SonodaNoriyukiN,
pubmed-author:SontaToshiyoT,
pubmed-author:SumimotoHidekiH,
pubmed-author:WallerC ACA
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
332
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
927-33
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:15922295-Administration, Oral,
pubmed-meshheading:15922295-Aldehydes,
pubmed-meshheading:15922295-Angiotensin II,
pubmed-meshheading:15922295-Angiotensin II Type 1 Receptor Blockers,
pubmed-meshheading:15922295-Angiotensins,
pubmed-meshheading:15922295-Animals,
pubmed-meshheading:15922295-Body Weight,
pubmed-meshheading:15922295-Deoxyguanosine,
pubmed-meshheading:15922295-Diabetes Mellitus, Type 2,
pubmed-meshheading:15922295-Disease Models, Animal,
pubmed-meshheading:15922295-Insulin,
pubmed-meshheading:15922295-Islets of Langerhans,
pubmed-meshheading:15922295-Membrane Glycoproteins,
pubmed-meshheading:15922295-Membrane Transport Proteins,
pubmed-meshheading:15922295-Mice,
pubmed-meshheading:15922295-Mice, Inbred C57BL,
pubmed-meshheading:15922295-NADPH Oxidase,
pubmed-meshheading:15922295-Oxidative Stress,
pubmed-meshheading:15922295-Phosphoproteins,
pubmed-meshheading:15922295-Rats,
pubmed-meshheading:15922295-Rats, Inbred OLETF,
pubmed-meshheading:15922295-Rats, Long-Evans,
pubmed-meshheading:15922295-Tetrazoles,
pubmed-meshheading:15922295-Time Factors,
pubmed-meshheading:15922295-Valine
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist.
|
|
pubmed:affiliation |
Department of Medicine and Bioregulatory Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
