| pubmed-article:15920553 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15920553 | lifeskim:mentions | umls-concept:C0033325 | lld:lifeskim |
| pubmed-article:15920553 | lifeskim:mentions | umls-concept:C0079744 | lld:lifeskim |
| pubmed-article:15920553 | lifeskim:mentions | umls-concept:C0079611 | lld:lifeskim |
| pubmed-article:15920553 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:15920553 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:15920553 | pubmed:dateCreated | 2005-7-21 | lld:pubmed |
| pubmed-article:15920553 | pubmed:abstractText | Diffuse large B-cell lymphoma (DLBCL) has been shown to be comprised of at least two prognostic entities, depending on its resemblance to normal germinal center or activated B cells, using global gene expression profiling. Also, the expression patterns of bcl-6, CD10 and IRF-4 (also known as MUM1) have been suggested as alternative means of identifying the germinal- and nongerminal center (activated B-cell like) groups. In the present study, we evaluated by immunohistochemistry the expression patterns of CD10, bcl-6, IRF-4 and bcl-2 in a large material of 161 DLBCL patients. Using two different approaches, patients with germinal center phenotype displayed a significantly better survival than the nongerminal center group. Positive staining for bcl-6 or CD10 predicted for superior survival, while expression of IRF-4 alone showed no association with prognosis. Furthermore, expression of bcl-2 was associated with worse event-free survival and overall survival. In a multivariate analysis, a high international prognostic index score (3-5), non-GC phenotype and bcl-2 were independent adverse prognostic factors. Here we confirm the prognostic importance of determining the germinal- or nongerminal center phenotype in patients with DLBCL. | lld:pubmed |
| pubmed-article:15920553 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15920553 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15920553 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15920553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15920553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15920553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15920553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15920553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15920553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15920553 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15920553 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15920553 | pubmed:issn | 0893-3952 | lld:pubmed |
| pubmed-article:15920553 | pubmed:author | pubmed-author:DictorMichael... | lld:pubmed |
| pubmed-article:15920553 | pubmed:author | pubmed-author:BookMajlisM | lld:pubmed |
| pubmed-article:15920553 | pubmed:author | pubmed-author:ThunbergUlfU | lld:pubmed |
| pubmed-article:15920553 | pubmed:author | pubmed-author:EnbladGunilla... | lld:pubmed |
| pubmed-article:15920553 | pubmed:author | pubmed-author:SundströmChri... | lld:pubmed |
| pubmed-article:15920553 | pubmed:author | pubmed-author:RoosGöranG | lld:pubmed |
| pubmed-article:15920553 | pubmed:author | pubmed-author:RosenquistRic... | lld:pubmed |
| pubmed-article:15920553 | pubmed:author | pubmed-author:HagbergHansH | lld:pubmed |
| pubmed-article:15920553 | pubmed:author | pubmed-author:BacklinCarinC | lld:pubmed |
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| pubmed-article:15920553 | pubmed:author | pubmed-author:BerglundMatti... | lld:pubmed |
| pubmed-article:15920553 | pubmed:author | pubmed-author:Cavallin-Ståh... | lld:pubmed |
| pubmed-article:15920553 | pubmed:author | pubmed-author:LinderothJoha... | lld:pubmed |
| pubmed-article:15920553 | pubmed:author | pubmed-author:JerkemanMatsM | lld:pubmed |
| pubmed-article:15920553 | pubmed:author | pubmed-author:Rehn-Eriksson... | lld:pubmed |
| pubmed-article:15920553 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15920553 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:15920553 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15920553 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15920553 | pubmed:pagination | 1113-20 | lld:pubmed |
| pubmed-article:15920553 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:15920553 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15920553 | pubmed:articleTitle | Evaluation of immunophenotype in diffuse large B-cell lymphoma and its impact on prognosis. | lld:pubmed |
| pubmed-article:15920553 | pubmed:affiliation | Department of Oncology, Radiology, and Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden. Mattias.Berlund@genpat.uu.se | lld:pubmed |
| pubmed-article:15920553 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15920553 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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