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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1992-6-26
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pubmed:abstractText |
The lambda 5 gene is a homolog of immunoglobulin J lambda-C lambda genes, expressed specifically in immature B-lineage cells. Lambda 5-encoded molecules form membrane complexes with mu or D mu proteins in association with an additional protein specifically expressed in immature B cells that is encoded by the Vpre-B gene. We have generated mice in which the lambda 5 gene is inactivated by targeted gene disruption in embryonic stem cells. In these mice, B cell development in the bone marrow is blocked at the pre-B cell stage. However, the blockade is leaky, allowing B cells to populate the peripheral immune system at a low rate. These cells are allelically excluded and able to respond to antigen.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
69
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pubmed:geneSymbol |
&lgr;5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
823-31
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1591779-Animals,
pubmed-meshheading:1591779-B-Lymphocytes,
pubmed-meshheading:1591779-Base Sequence,
pubmed-meshheading:1591779-Cell Differentiation,
pubmed-meshheading:1591779-Female,
pubmed-meshheading:1591779-Genes, Immunoglobulin,
pubmed-meshheading:1591779-Hematopoietic Stem Cells,
pubmed-meshheading:1591779-Humans,
pubmed-meshheading:1591779-Immunoglobulin Constant Regions,
pubmed-meshheading:1591779-Immunoglobulin Joining Region,
pubmed-meshheading:1591779-Immunoglobulin Variable Region,
pubmed-meshheading:1591779-Immunoglobulin lambda-Chains,
pubmed-meshheading:1591779-Male,
pubmed-meshheading:1591779-Mice,
pubmed-meshheading:1591779-Mice, Inbred C57BL,
pubmed-meshheading:1591779-Molecular Sequence Data,
pubmed-meshheading:1591779-Mutagenesis, Insertional,
pubmed-meshheading:1591779-Mutation,
pubmed-meshheading:1591779-Neomycin,
pubmed-meshheading:1591779-Polymerase Chain Reaction,
pubmed-meshheading:1591779-Recombination, Genetic
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pubmed:year |
1992
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pubmed:articleTitle |
A critical role of lambda 5 protein in B cell development.
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pubmed:affiliation |
Institute for Genetics, University of Cologne, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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