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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-5-19
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pubmed:abstractText |
Hypoxia is a common feature of many cancers, contributing to tumour progression as well as potentially compromising radiotherapy and chemotherapy. Hypoxia-inducible factor 1 (HIF-1) is an essential component in changing the transcriptional response of tumours under hypoxia and it targets the transcription of many genes involved in cancer biology. Over-expression of HIF-1 has been associated with increased patient mortality in several cancer types. Regulation of HIF-1 by the signalling molecule nitric oxide (NO) is becoming increasingly recognised.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/HIF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/omega-N-Methylarginine
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0035-8843
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
153-8
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pubmed:dateRevised |
2008-11-20
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pubmed:meshHeading |
pubmed-meshheading:15901372-Carcinoma, Squamous Cell,
pubmed-meshheading:15901372-Cell Hypoxia,
pubmed-meshheading:15901372-DNA-Binding Proteins,
pubmed-meshheading:15901372-Enzyme Inhibitors,
pubmed-meshheading:15901372-Humans,
pubmed-meshheading:15901372-Hypoxia-Inducible Factor 1,
pubmed-meshheading:15901372-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:15901372-Mouth Neoplasms,
pubmed-meshheading:15901372-Neoplasm Proteins,
pubmed-meshheading:15901372-Nitric Oxide,
pubmed-meshheading:15901372-Nitric Oxide Synthase,
pubmed-meshheading:15901372-Nuclear Proteins,
pubmed-meshheading:15901372-Transcription Factors,
pubmed-meshheading:15901372-Tumor Cells, Cultured,
pubmed-meshheading:15901372-omega-N-Methylarginine
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pubmed:year |
2005
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pubmed:articleTitle |
Hunterian Lecture. Regulation of hypoxia-inducible factor 1 (HIF-1) by nitric oxide in oral squamous cell carcinoma.
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pubmed:affiliation |
Department of Head and Neck Surgery, Queen Alexandra Hospital, Portsmouth, UK. peter.brennan@porthosp.nhs.uk
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pubmed:publicationType |
Research Support, Non-U.S. Gov't,
Lectures
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