| pubmed-article:15897344 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15897344 | lifeskim:mentions | umls-concept:C0018801 | lld:lifeskim |
| pubmed-article:15897344 | lifeskim:mentions | umls-concept:C0026820 | lld:lifeskim |
| pubmed-article:15897344 | lifeskim:mentions | umls-concept:C0034785 | lld:lifeskim |
| pubmed-article:15897344 | lifeskim:mentions | umls-concept:C1166803 | lld:lifeskim |
| pubmed-article:15897344 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:15897344 | lifeskim:mentions | umls-concept:C1514762 | lld:lifeskim |
| pubmed-article:15897344 | lifeskim:mentions | umls-concept:C2252687 | lld:lifeskim |
| pubmed-article:15897344 | lifeskim:mentions | umls-concept:C0332453 | lld:lifeskim |
| pubmed-article:15897344 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:15897344 | pubmed:dateCreated | 2005-5-24 | lld:pubmed |
| pubmed-article:15897344 | pubmed:abstractText | Desensitization and downregulation of myocardial beta-adrenergic receptors (betaARs) are initiated by the increase in betaAR kinase 1 (betaARK1) levels. By interacting with betaARK1 through the phosphoinositide kinase (PIK) domain, phosphoinositide 3-kinase (PI3K) is targeted to agonist-stimulated betaARs, where it regulates endocytosis. We tested the hypothesis that inhibition of receptor-targeted PI3K activity would alter receptor trafficking and ameliorate betaAR signaling, ultimately improving contractility of failing cardiomyocytes. | lld:pubmed |
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| pubmed-article:15897344 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15897344 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15897344 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15897344 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15897344 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15897344 | pubmed:month | May | lld:pubmed |
| pubmed-article:15897344 | pubmed:issn | 1524-4539 | lld:pubmed |
| pubmed-article:15897344 | pubmed:author | pubmed-author:Naga... | lld:pubmed |
| pubmed-article:15897344 | pubmed:author | pubmed-author:RockmanHoward... | lld:pubmed |
| pubmed-article:15897344 | pubmed:author | pubmed-author:PerrinoCinzia... | lld:pubmed |
| pubmed-article:15897344 | pubmed:author | pubmed-author:HataJonathan... | lld:pubmed |
| pubmed-article:15897344 | pubmed:author | pubmed-author:MilanoCarmelo... | lld:pubmed |
| pubmed-article:15897344 | pubmed:author | pubmed-author:SchroderJacob... | lld:pubmed |
| pubmed-article:15897344 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15897344 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:15897344 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:15897344 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15897344 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15897344 | pubmed:pagination | 2579-87 | lld:pubmed |
| pubmed-article:15897344 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:15897344 | pubmed:meshHeading | pubmed-meshheading:15897344... | lld:pubmed |
| pubmed-article:15897344 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15897344 | pubmed:articleTitle | Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex. | lld:pubmed |
| pubmed-article:15897344 | pubmed:affiliation | Department of Medicine, Cell Biology and Molecular Genetics, Duke University Medical Center, Durham, NC 27710, USA. | lld:pubmed |
| pubmed-article:15897344 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15897344 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15897344 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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