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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2005-5-24
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pubmed:abstractText |
Desensitization and downregulation of myocardial beta-adrenergic receptors (betaARs) are initiated by the increase in betaAR kinase 1 (betaARK1) levels. By interacting with betaARK1 through the phosphoinositide kinase (PIK) domain, phosphoinositide 3-kinase (PI3K) is targeted to agonist-stimulated betaARs, where it regulates endocytosis. We tested the hypothesis that inhibition of receptor-targeted PI3K activity would alter receptor trafficking and ameliorate betaAR signaling, ultimately improving contractility of failing cardiomyocytes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
24
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2579-87
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15897344-Animals,
pubmed-meshheading:15897344-Endosomes,
pubmed-meshheading:15897344-Gene Therapy,
pubmed-meshheading:15897344-Heart Failure,
pubmed-meshheading:15897344-Isoproterenol,
pubmed-meshheading:15897344-Mice,
pubmed-meshheading:15897344-Mice, Transgenic,
pubmed-meshheading:15897344-Myocardial Contraction,
pubmed-meshheading:15897344-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:15897344-Protein Binding,
pubmed-meshheading:15897344-Protein Transport,
pubmed-meshheading:15897344-Receptors, Adrenergic, beta,
pubmed-meshheading:15897344-Signal Transduction,
pubmed-meshheading:15897344-Swine,
pubmed-meshheading:15897344-beta-Adrenergic Receptor Kinases
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pubmed:year |
2005
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pubmed:articleTitle |
Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex.
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pubmed:affiliation |
Department of Medicine, Cell Biology and Molecular Genetics, Duke University Medical Center, Durham, NC 27710, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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