Source:http://linkedlifedata.com/resource/pubmed/id/15893410
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2006-4-18
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pubmed:abstractText |
We report that a peripheral injection of Escherichia coli produces both anterograde and retrograde amnesia in 24 month old, but not 3 month old rats for memories that depend on the hippocampus, that is, memory of context, contextual fear, and place learning. The anterograde effect was restricted to measures of long-term memory. Short-term memory was not affected, nor did E. coli produce amnesia for auditory-cue fear conditioning. There were no age related effects on memory in vehicle-treated rats. In addition to these age-related cognitive effects of E.coli, we report that it produced a marked increased in IL-1beta levels in the hippocampus, but not in parietal cortex or serum. These findings support the hypothesis that age is a vulnerability factor that increases the likelihood that an immune challenge will produce a cognitive impairment. It is possible that this cognitive vulnerability is mediated by age-related changes in the glial environment that results in an exaggerated brain pro-inflammatory response to infection.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1558-1497
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
723-32
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15893410-Acoustic Stimulation,
pubmed-meshheading:15893410-Aging,
pubmed-meshheading:15893410-Amnesia, Anterograde,
pubmed-meshheading:15893410-Amnesia, Retrograde,
pubmed-meshheading:15893410-Animals,
pubmed-meshheading:15893410-Conditioning (Psychology),
pubmed-meshheading:15893410-Escherichia coli Infections,
pubmed-meshheading:15893410-Fear,
pubmed-meshheading:15893410-Hippocampus,
pubmed-meshheading:15893410-Interleukin-1,
pubmed-meshheading:15893410-Male,
pubmed-meshheading:15893410-Maze Learning,
pubmed-meshheading:15893410-Memory Disorders,
pubmed-meshheading:15893410-Rats
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pubmed:year |
2006
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pubmed:articleTitle |
Peripheral infection and aging interact to impair hippocampal memory consolidation.
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pubmed:affiliation |
Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309-0345, USA. rbarr@psych.colorado.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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