Linked Life Data

15891034

Source:http://linkedlifedata.com/resource/pubmed/id/15891034

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-5-13
pubmed:abstractText
Ligand interactions of a zebrafish bradykinin (BK) receptor expressed in vitro were characterized by measuring inositol phosphate accumulation. The ligands were analogues of zebrafish BK. Substitutions of Arg1, Gly4, Ser6, Pro7, Leu8, and Arg9 caused greatly reduced potency and maximum response. The Pro3 to Ala analogue had higher potency, but lower maximum response. These and other differences show that the zebrafish BK receptor has a ligand-interaction profile that is distinct from mammalian B1 and B2 receptors and from the previously characterized BK receptor in trout stomach. The results increase our understanding of the evolution of BK receptors and their ligands.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
1040
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
246-8
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Bradykinin receptors in the zebrafish (Danio rerio).
pubmed:affiliation
Department of Neuroscience, Unit of Pharmacology, Uppsala University, Sweden. torun.duner@neuro.uu.se
pubmed:publicationType
Journal Article, Review