| pubmed-article:15890945 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15890945 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:15890945 | lifeskim:mentions | umls-concept:C1325725 | lld:lifeskim |
| pubmed-article:15890945 | lifeskim:mentions | umls-concept:C0025919 | lld:lifeskim |
| pubmed-article:15890945 | lifeskim:mentions | umls-concept:C0026724 | lld:lifeskim |
| pubmed-article:15890945 | lifeskim:mentions | umls-concept:C0475463 | lld:lifeskim |
| pubmed-article:15890945 | lifeskim:mentions | umls-concept:C0042196 | lld:lifeskim |
| pubmed-article:15890945 | lifeskim:mentions | umls-concept:C0449444 | lld:lifeskim |
| pubmed-article:15890945 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15890945 | lifeskim:mentions | umls-concept:C1521801 | lld:lifeskim |
| pubmed-article:15890945 | lifeskim:mentions | umls-concept:C0205373 | lld:lifeskim |
| pubmed-article:15890945 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:15890945 | pubmed:dateCreated | 2005-5-13 | lld:pubmed |
| pubmed-article:15890945 | pubmed:abstractText | We have recently developed a candidate human immunodeficiency virus type 1 (HIV-1) vaccine model, based on virus-like particles (VLPs) expressing gp120 from a Ugandan HIV-1 isolate of clade A (HIV-VLP(A)s), which shows the induction of neutralizing antibodies as well as cytotoxic T lymphocytes (CTL) in BALB/c mice by intraperitoneal (i.p.) administration. In the present study, immunization experiments based on a multiple-dose regimen have been performed with BALB/c mice to compare different routes of administration. i.p. and intranasal (i.n.), but not oral, administration induce systemic as well as mucosal (vaginal and intestinal) immunoglobulin G (IgG) and IgA responses. These immune sera exhibit >50% ex vivo neutralizing activity against both autologous and heterologous primary isolates. Furthermore, the administration of HIV-VLP(A)s by the i.n. immunization route induces a specific CTL activity, although at lower efficiency than the i.p. route. The HIV-VLP(A)s represent an efficient strategy to stimulate both arms of immunity; furthermore, the induction of specific humoral immunity at mucosal sites, which nowadays represent the main port of entry for HIV-1 infection, is of great interest. All these properties, and the possible cross-clade in vivo protection, could make these HIV-VLP(A)s a good candidate for a mono- and multicomponent worldwide preventive vaccine approach not restricted to high-priority regions, such as sub-Saharan countries. | lld:pubmed |
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| pubmed-article:15890945 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15890945 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15890945 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15890945 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15890945 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15890945 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15890945 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:15890945 | pubmed:author | pubmed-author:BuonaguroLL | lld:pubmed |
| pubmed-article:15890945 | pubmed:author | pubmed-author:BuonaguroF... | lld:pubmed |
| pubmed-article:15890945 | pubmed:author | pubmed-author:TorneselloM... | lld:pubmed |
| pubmed-article:15890945 | pubmed:author | pubmed-author:BiryahwahoBB | lld:pubmed |
| pubmed-article:15890945 | pubmed:author | pubmed-author:ViscianoM LML | lld:pubmed |
| pubmed-article:15890945 | pubmed:author | pubmed-author:TagliamonteMM | lld:pubmed |
| pubmed-article:15890945 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15890945 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:15890945 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15890945 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15890945 | pubmed:pagination | 7059-67 | lld:pubmed |
| pubmed-article:15890945 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15890945 | pubmed:meshHeading | pubmed-meshheading:15890945... | lld:pubmed |
| pubmed-article:15890945 | pubmed:meshHeading | pubmed-meshheading:15890945... | lld:pubmed |
| pubmed-article:15890945 | pubmed:meshHeading | pubmed-meshheading:15890945... | lld:pubmed |
