Linked Life Data

15890415

Source:http://linkedlifedata.com/resource/pubmed/id/15890415

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pubmed-article:15890415pubmed:abstractTextWe report the activities of a novel nucleoside analog against HIV. This nucleoside (KP-1212) is not a chain terminator but exerts its antiviral effects via mutagenesis of the viral genome. Serial passaging of HIV in the presence of KP-1212 causes an increase in the mutation rate of the virus leading to viral ablation. HIV strains resistant to KP-1212 have not yet been isolated. Quite to the contrary, virus treated with KP-1212 exhibited an increased sensitivity not only to KP-1212 but also to another nucleoside reverse transcriptase inhibitor (NRTI), zidovudine. HIV strains resistant to other NRTIs (e.g. zidovudine, lamivudine, stavudine, abacavir, etc.) exhibited no cross-resistance towards KP-1212. Multiple assays confirmed that KP-1212 has a favorable (low) genotoxicity profile when compared to some approved antiviral nucleosides. In addition, KP-1212 is not toxic to mitochondria nor does it exhibit any inhibitory effects on mitochondrial DNA synthesis.lld:pubmed
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pubmed-article:15890415pubmed:dateRevised2007-9-12lld:pubmed
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pubmed-article:15890415pubmed:year2005lld:pubmed
pubmed-article:15890415pubmed:articleTitleKP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis.lld:pubmed
pubmed-article:15890415pubmed:affiliationKoronis Pharmaceuticals Inc., 12277 134th Ct. N.E. Redmond, WA 98052, USA. kharris@koronispharma.comlld:pubmed
pubmed-article:15890415pubmed:publicationTypeJournal Articlelld:pubmed
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