Source:http://linkedlifedata.com/resource/pubmed/id/15890415
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2005-6-13
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pubmed:abstractText |
We report the activities of a novel nucleoside analog against HIV. This nucleoside (KP-1212) is not a chain terminator but exerts its antiviral effects via mutagenesis of the viral genome. Serial passaging of HIV in the presence of KP-1212 causes an increase in the mutation rate of the virus leading to viral ablation. HIV strains resistant to KP-1212 have not yet been isolated. Quite to the contrary, virus treated with KP-1212 exhibited an increased sensitivity not only to KP-1212 but also to another nucleoside reverse transcriptase inhibitor (NRTI), zidovudine. HIV strains resistant to other NRTIs (e.g. zidovudine, lamivudine, stavudine, abacavir, etc.) exhibited no cross-resistance towards KP-1212. Multiple assays confirmed that KP-1212 has a favorable (low) genotoxicity profile when compared to some approved antiviral nucleosides. In addition, KP-1212 is not toxic to mitochondria nor does it exhibit any inhibitory effects on mitochondrial DNA synthesis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5,6-dihydro-5-azacytidine,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-HIV Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Azacitidine,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleosides,
http://linkedlifedata.com/resource/pubmed/chemical/Reverse Transcriptase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Zidovudine
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0166-3542
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-9
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pubmed:dateRevised |
2007-9-12
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pubmed:meshHeading |
pubmed-meshheading:15890415-Animals,
pubmed-meshheading:15890415-Anti-HIV Agents,
pubmed-meshheading:15890415-Azacitidine,
pubmed-meshheading:15890415-Cell Line,
pubmed-meshheading:15890415-Cricetinae,
pubmed-meshheading:15890415-HIV Infections,
pubmed-meshheading:15890415-HIV-1,
pubmed-meshheading:15890415-Humans,
pubmed-meshheading:15890415-Microbial Sensitivity Tests,
pubmed-meshheading:15890415-Mutation,
pubmed-meshheading:15890415-Nucleosides,
pubmed-meshheading:15890415-Reverse Transcriptase Inhibitors,
pubmed-meshheading:15890415-Zidovudine
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pubmed:year |
2005
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pubmed:articleTitle |
KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis.
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pubmed:affiliation |
Koronis Pharmaceuticals Inc., 12277 134th Ct. N.E. Redmond, WA 98052, USA. kharris@koronispharma.com
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pubmed:publicationType |
Journal Article
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