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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2005-5-17
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pubmed:abstractText |
Angiotensin II (Ang II) participates in vascular fibrosis. Transforming growth factor-beta (TGF-beta) is considered the most important fibrotic factor, and Smad proteins are essential components of the TGF-beta signaling system. Our aim was to investigate whether Ang II activates the Smad pathway in vascular cells and its potential role in fibrosis, evaluating connective tissue growth factor (CTGF) and extracellular matrix (ECM) proteins.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Connective Tissue Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Ctgf protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ctgf protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Angiotensin, Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/Smad Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Smad4 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
17
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2509-17
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15883213-Active Transport, Cell Nucleus,
pubmed-meshheading:15883213-Angiotensin II,
pubmed-meshheading:15883213-Animals,
pubmed-meshheading:15883213-Connective Tissue Growth Factor,
pubmed-meshheading:15883213-Extracellular Matrix Proteins,
pubmed-meshheading:15883213-Fibrosis,
pubmed-meshheading:15883213-Immediate-Early Proteins,
pubmed-meshheading:15883213-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:15883213-Mitogen-Activated Protein Kinases,
pubmed-meshheading:15883213-Muscle, Smooth, Vascular,
pubmed-meshheading:15883213-Rats,
pubmed-meshheading:15883213-Rats, Wistar,
pubmed-meshheading:15883213-Receptor, Angiotensin, Type 1,
pubmed-meshheading:15883213-Smad Proteins,
pubmed-meshheading:15883213-Smad2 Protein,
pubmed-meshheading:15883213-Smad4 Protein,
pubmed-meshheading:15883213-Transforming Growth Factor beta,
pubmed-meshheading:15883213-Up-Regulation
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pubmed:year |
2005
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pubmed:articleTitle |
Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism.
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pubmed:affiliation |
Vascular and Renal Research Laboratory, Fundación Jiménez Díaz, Universidad Autónoma Madrid, Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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