|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003438,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0030705,
umls-concept:C0040018,
umls-concept:C0079411,
umls-concept:C0205314,
umls-concept:C0205360,
umls-concept:C0254071,
umls-concept:C0439851,
umls-concept:C0679622,
umls-concept:C1280500,
umls-concept:C1552596,
umls-concept:C1947931,
umls-concept:C1956346,
umls-concept:C2825027
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2006-2-7
|
|
pubmed:abstractText |
Thrombin, a pluripotential effector enzyme with prothrombotic, proinflammatory, and mitogenic properties, plays a pivotal role in the pathobiology and clinical expression of atherothrombotic coronary artery disease. Existing anticoagulant drugs have not been shown to attenuate thrombin generation or activity consistently. We sought to investigate the effect of DX-9065a on thrombin generation and inhibition in patients with stable CAD. DX-9065a is a small-molecule, synthetic, direct inhibitor of factor Xa.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1879-2472
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
117
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
439-46
|
|
pubmed:meshHeading |
pubmed-meshheading:15882894-Aged,
pubmed-meshheading:15882894-Anticoagulants,
pubmed-meshheading:15882894-Antithrombin III,
pubmed-meshheading:15882894-Coronary Artery Disease,
pubmed-meshheading:15882894-Female,
pubmed-meshheading:15882894-Humans,
pubmed-meshheading:15882894-Male,
pubmed-meshheading:15882894-Middle Aged,
pubmed-meshheading:15882894-Naphthalenes,
pubmed-meshheading:15882894-Propionic Acids,
pubmed-meshheading:15882894-Thrombin
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Effect of the novel direct factor Xa inhibitor DX-9065a on thrombin generation and inhibition among patients with stable atherosclerotic coronary artery disease.
|
|
pubmed:affiliation |
Duke Cardiovascular Thrombosis Center, Duke University School of Medicine, Durham, NC 27710 USA.
|
|
pubmed:publicationType |
Journal Article,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
