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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
9
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pubmed:dateCreated |
2005-5-9
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pubmed:abstractText |
Inhibition of the complement cascade at C5 prevents formation of pro-inflammatory molecules C5a and C5b-9, which play a key role in allograft rejection. The present study was undertaken to determine whether blocking terminal complement with anti-C5 monoclonal antibody (mAb) alone or combined with cyclosporine (CsA) would prevent acute vascular rejection (AVR) in a mouse cardiac allograft model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0041-1337
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1121-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15880054-Acute Disease,
pubmed-meshheading:15880054-Animals,
pubmed-meshheading:15880054-Antibodies, Monoclonal,
pubmed-meshheading:15880054-Blood Vessels,
pubmed-meshheading:15880054-Complement C5,
pubmed-meshheading:15880054-Cyclosporine,
pubmed-meshheading:15880054-Flow Cytometry,
pubmed-meshheading:15880054-Graft Rejection,
pubmed-meshheading:15880054-Heart Transplantation,
pubmed-meshheading:15880054-Isoantibodies,
pubmed-meshheading:15880054-Male,
pubmed-meshheading:15880054-Mice,
pubmed-meshheading:15880054-Mice, Inbred BALB C,
pubmed-meshheading:15880054-Mice, Inbred C3H,
pubmed-meshheading:15880054-Transplantation, Homologous
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pubmed:year |
2005
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|
pubmed:articleTitle |
Prevention of acute vascular rejection by a functionally blocking anti-C5 monoclonal antibody combined with cyclosporine.
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pubmed:affiliation |
Multi-Organ Transplant Program, London Health Sciences Centre, London, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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