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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1992-6-23
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pubmed:abstractText |
Disseminated Mycobacterium avium infections are common in patients with AIDS and result in a reduced life expectancy. Human monocytes/macrophages are important target cells for both human immunodeficiency virus (HIV) and M. avium. We have studied the interaction in vitro of M. avium and HIV type 1 (HIV-1) in human macrophages. Human monocytes isolated from the peripheral blood of healthy individuals were infected with HIV-1, M. avium, or both. The intracellular growth of M. avium and the replication of HIV-1 were monitored for up to 5 weeks. Intracellular mycobacterial growth was seen in all M. avium infected cell cultures and was paralleled by increased production of interleukin 1 alpha and beta. Preinfection of the macrophages with HIV-1 reduced the interleukin 1 production and accelerated the intracellular growth of M. avium. These findings may explain in part the impaired control of mycobacterial infections seen with patients with AIDS.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-1910011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-2017230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-2253685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-2380348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-2429124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-2491838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-2612049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-2704931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-2717618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-2834450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-2912355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-2964477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-3011909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-3013342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-3014648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-3014936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-3016903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-3206059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-3258626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-3260578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-3264291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-3436314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-3484390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-3541122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-3771767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1587613-3972985
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2453-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1992
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pubmed:articleTitle |
Human immunodeficiency virus type 1 enhances intracellular growth of Mycobacterium avium in human macrophages.
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pubmed:affiliation |
National Bacteriological Laboratory, Karolinska Institute, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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