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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-8-4
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pubmed:abstractText |
Natural killer (NK) cells must be able to eliminate infected and transformed cells while remaining tolerant of normal cells. NK-cell self-tolerance is thought to be maintained by self-major histocompatibility complex (MHC) class I recognition; however, there are examples where NK cells are not regulated by MHC class I and yet remain self-tolerant. Here, we show that 2B4 (CD244) and CD48 represent a second system for murine NK-cell self-recognition. 2B4 and MHC class I receptors act nonredundantly to inhibit NK lysis of syngeneic tumor cells. NK cells from beta2 microglobulin (beta2m)-deficient mice and NK cells that lack expression of self-MHC-binding inhibitory receptors are inhibited by 2B4. Moreover, we provide the first in vivo evidence for MHC-independent NK self-recognition in a bone marrow rejection assay. These data suggest that NK-cell self-tolerance can be mediated by molecules other than MHC.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-10358137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-10856220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-11244039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-11513145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-11782535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-11861289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-11917118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-12077237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-14530376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-14604968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-15123744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-15607804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-15634901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-15728129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-15771571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-1853205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-1946452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-2201309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-3951539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-8898935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-9059881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-9120271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-9463411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-9548460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-9586357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15870174-9834253
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1337-40
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15870174-Animals,
pubmed-meshheading:15870174-Antigens, CD,
pubmed-meshheading:15870174-Bone Marrow Transplantation,
pubmed-meshheading:15870174-Cytotoxicity, Immunologic,
pubmed-meshheading:15870174-Graft Rejection,
pubmed-meshheading:15870174-Histocompatibility Antigens Class I,
pubmed-meshheading:15870174-Killer Cells, Natural,
pubmed-meshheading:15870174-Membrane Glycoproteins,
pubmed-meshheading:15870174-Mice,
pubmed-meshheading:15870174-Mice, Knockout,
pubmed-meshheading:15870174-Neoplasms,
pubmed-meshheading:15870174-Receptors, Immunologic,
pubmed-meshheading:15870174-Self Tolerance,
pubmed-meshheading:15870174-Transplantation, Isogeneic,
pubmed-meshheading:15870174-beta 2-Microglobulin
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pubmed:year |
2005
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pubmed:articleTitle |
2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice.
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pubmed:affiliation |
Department of Pathology, University of Chicago, 5841 S Maryland Ave, S-315 MC3083, Chicago, IL 60637, USA. mcnerney@midway.uchicago.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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