|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007301,
umls-concept:C0007303,
umls-concept:C0009331,
umls-concept:C0011164,
umls-concept:C0017337,
umls-concept:C0086418,
umls-concept:C0205217,
umls-concept:C0205234,
umls-concept:C0221198,
umls-concept:C0332281,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C1157968,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C2245575
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|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2005-5-3
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|
pubmed:abstractText |
Articular cartilage degeneration in osteoarthritis (OA) involves excessive degradation of extracellular matrix (ECM) and chondrocyte differentiation (hypertrophy). We determined the interrelationship between the extent of collagen cleavage by collagenase, cartilage degeneration, and differentiation related gene expression in patella-femoral condylar cartilages of patients bearing very early focal OA-like articular cartilage lesions.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
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pubmed:issn |
0315-162X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
32
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
876-86
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15868625-Aged,
pubmed-meshheading:15868625-Cartilage, Articular,
pubmed-meshheading:15868625-Cell Differentiation,
pubmed-meshheading:15868625-Chondrocytes,
pubmed-meshheading:15868625-Collagen Type II,
pubmed-meshheading:15868625-Cytokines,
pubmed-meshheading:15868625-Early Diagnosis,
pubmed-meshheading:15868625-Extracellular Matrix Proteins,
pubmed-meshheading:15868625-Female,
pubmed-meshheading:15868625-Gene Expression Profiling,
pubmed-meshheading:15868625-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:15868625-Humans,
pubmed-meshheading:15868625-Knee Joint,
pubmed-meshheading:15868625-Male,
pubmed-meshheading:15868625-Metalloproteases,
pubmed-meshheading:15868625-Middle Aged,
pubmed-meshheading:15868625-Up-Regulation
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|
pubmed:year |
2005
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|
pubmed:articleTitle |
Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions.
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pubmed:affiliation |
Joint Diseases Laboratory, Shriners Hospitals for Children, Montreal, Quebec, Canada. etchetina@shriners.mcgill.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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