Source:http://linkedlifedata.com/resource/pubmed/id/15856417
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2005-4-27
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pubmed:abstractText |
Diphyllin isolated from Haplophyllum bucharicum Litv. (Rutaceae), an endemic plant of Uzbekistan, displayed a moderate antiproliferative activity towards human monocytes (IC50 = 35.2 microM) and Leishmania promastigotes (IC50 = 14.4 microM), by a mechanism of action that involved interaction with macromolecules and resulted in cell cycle arrest in the S-phase and inhibition of protein synthesis. In the intracellular amastigote form of the parasite, diphyllin exerted a strong specific inhibitory activity (IC50 = 0.2 microM) resulting from the inhibition of parasite internalization within macrophages. This property was mainly due to modulation of macrophage phagocytosis and, to a lesser extent, it also involved interference with surface molecules of the promastigote membrane.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antiprotozoal Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Dioxolanes,
http://linkedlifedata.com/resource/pubmed/chemical/Lignans,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/diphyllin
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0032-0943
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
366-9
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pubmed:meshHeading |
pubmed-meshheading:15856417-Animals,
pubmed-meshheading:15856417-Antiprotozoal Agents,
pubmed-meshheading:15856417-Cell Cycle,
pubmed-meshheading:15856417-Dioxolanes,
pubmed-meshheading:15856417-Leishmania,
pubmed-meshheading:15856417-Leishmaniasis,
pubmed-meshheading:15856417-Lignans,
pubmed-meshheading:15856417-Macrophages,
pubmed-meshheading:15856417-Parasitic Sensitivity Tests,
pubmed-meshheading:15856417-Phytotherapy,
pubmed-meshheading:15856417-Plant Components, Aerial,
pubmed-meshheading:15856417-Plant Extracts,
pubmed-meshheading:15856417-Rutaceae
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pubmed:year |
2005
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pubmed:articleTitle |
In vitro antileishmanial activity of diphyllin isolated from Haplophyllum bucharicum.
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pubmed:affiliation |
Laboratoire de Parasitologie Hygiène et Zoologie, Faculté de Pharmacie, Marseille, France. Carole.Digiorgio@Pharmacie.univ-mrs.fr
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pubmed:publicationType |
Journal Article
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