Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-4-26
pubmed:abstractText
In patients with chronic hepatitis C, alanine aminotransferase (ALT) levels do not accurately reflect the extent of liver inflammation. The discrepancy between ALT level and liver damage could be related to the mode of cell death. In the present study, we quantified serum levels of apoptotic cytokeratin 18 (CK-18) neoepitopes that are generated by activated caspases during apoptosis. Apoptotic CK-18 neoepitopes were quantified by enzyme linked immunosorbent assay in sera from patients with chronic hepatitis C and elevated ALT levels (n = 72), patients with chronic hepatitis C and persistently normal ALT levels (n = 27) and healthy controls (n = 19). Serum CK-18 neoepitope levels were strongly correlated with ALT (r = 0.659, P < 0.0001) and the histology activity index (r = 0.374, P < 0.001). Patients with chronic hepatitis C and persistently normal ALT levels had higher apoptotic CK-18 neoepitope levels than healthy controls (P = 0.03) but lower levels than patients with chronic hepatitis C and elevated ALT levels (P < 0.001). Highest serum CK-18 neoepitope levels were observed in patients with cirrhosis (P = 0.002). Hence apoptotic CK-18 neoepitopes in serum of patients with chronic hepatitis C are associated with ALT level and histological liver damage. Serum apoptotic CK-18 neoepitope levels are elevated both in patients with chronic hepatitis C and elevated ALT levels as well as in patients with normal ALT levels indicating that also patients with chronic hepatitis C and normal ALT have an increased hepatocyte loss by apoptosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1352-0504
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
307-14
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15850472-Adult, pubmed-meshheading:15850472-Aged, pubmed-meshheading:15850472-Alanine Transaminase, pubmed-meshheading:15850472-Apoptosis, pubmed-meshheading:15850472-Biological Markers, pubmed-meshheading:15850472-Biopsy, Needle, pubmed-meshheading:15850472-Case-Control Studies, pubmed-meshheading:15850472-Chi-Square Distribution, pubmed-meshheading:15850472-Disease Progression, pubmed-meshheading:15850472-Female, pubmed-meshheading:15850472-Hepatitis C, Chronic, pubmed-meshheading:15850472-Humans, pubmed-meshheading:15850472-Immunohistochemistry, pubmed-meshheading:15850472-Keratins, pubmed-meshheading:15850472-Liver Function Tests, pubmed-meshheading:15850472-Male, pubmed-meshheading:15850472-Middle Aged, pubmed-meshheading:15850472-Probability, pubmed-meshheading:15850472-Prognosis, pubmed-meshheading:15850472-Risk Assessment, pubmed-meshheading:15850472-Sensitivity and Specificity, pubmed-meshheading:15850472-Severity of Illness Index, pubmed-meshheading:15850472-Statistics, Nonparametric
pubmed:year
2005
pubmed:articleTitle
Apoptotic cytokeratin 18 neoepitopes in serum of patients with chronic hepatitis C.
pubmed:affiliation
Klinik für Innere Medizin II, Universitätsklinikum des Saarlandes, 66421 Homburg/Saar, Germany.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't