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pubmed:abstractText |
POU1F1, a pituitary-specific transcription factor of the class 1 POU family, is crucial for the development and differentiation of the anterior pituitary gland. Mutations in the POU1F1 gene have been shown to be responsible for a syndrome of combined pituitary hormone deficiency (CPHD), including prolactin, growth hormone and thyroid-stimulating hormone deficiencies.
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pubmed:affiliation |
Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children 's Medical Center of Israel, Petah Tiqva, Israel.
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