Linked Life Data

15842627

Source:http://linkedlifedata.com/resource/pubmed/id/15842627

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-4-21
pubmed:databankReference
pubmed:abstractText
A prominent regulatory property of plant shaker-type K+ channels is the 'rundown' that causes channel closure upon membrane excision from the cell, implicating intracellular factor(s) in maintaining channel activity. One such factor has been identified as hydrolysable ATP-Mg although the mechanism for ATP function remains unknown. Here we report identification of phosphatidylinositol (PI) phosphates (PIPs) as essential regulators for the voltage-dependent and -independent activation of plant shaker-type channels such as SKOR, an outward rectifying K+ channel. Inhibition of PI kinase activity abolished the function of ATP-Mg in restoration of rundown channel activity, demonstrating that PIPs production by PI kinases and ATP-Mg underlies ATP-induced activation of the rundown channel. We also identified aluminum block as a common feature of the plant shaker-type channels and provided evidence that aluminum block of these channels may result from Al interaction with PIPs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0960-7412
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
433-43
pubmed:dateRevised
2006-11-7
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
An essential function of phosphatidylinositol phosphates in activation of plant shaker-type K+ channels.
pubmed:affiliation
Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA.
pubmed:publicationType
Journal Article