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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-4-19
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pubmed:abstractText |
Enhanced expression of CXCL16 has been demonstrated in atherosclerotic plaques and several properties have been attributed to CXCL16 that could influence the atherosclerotic process. CXCL16 exists in transmembrane and soluble forms. The transmembrane form acts as a scavenger receptor for oxidised LDL whereas the soluble form acts a chemoattractant for mainly CD8+ T cells. In addition, the soluble form of CXCL16 influences human aortic smooth muscle cell proliferation in vitro. In the present work, a human molecular genetic approach employing a common polymorphism within exon 4 of CXCL16 (181 Ala>Val) was used to investigate whether CXCL16 may be involved in the development of coronary artery disease. The polymorphism is located within the spacer region between the chemokine and transmembrane region and potentially influences an Ala/Val cleavage site, a site commonly used for the release of chemokines by tumour necrosis factor-alpha converting enzyme.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0954-6820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
257
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
415-22
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15836657-Amino Acid Sequence,
pubmed-meshheading:15836657-Analysis of Variance,
pubmed-meshheading:15836657-Angioplasty, Balloon, Coronary,
pubmed-meshheading:15836657-Case-Control Studies,
pubmed-meshheading:15836657-Chemokines, CXC,
pubmed-meshheading:15836657-Chi-Square Distribution,
pubmed-meshheading:15836657-Coronary Angiography,
pubmed-meshheading:15836657-Coronary Stenosis,
pubmed-meshheading:15836657-Female,
pubmed-meshheading:15836657-Follow-Up Studies,
pubmed-meshheading:15836657-Gene Frequency,
pubmed-meshheading:15836657-Humans,
pubmed-meshheading:15836657-Male,
pubmed-meshheading:15836657-Membrane Proteins,
pubmed-meshheading:15836657-Middle Aged,
pubmed-meshheading:15836657-Molecular Sequence Data,
pubmed-meshheading:15836657-Myocardial Infarction,
pubmed-meshheading:15836657-Polymorphism, Genetic,
pubmed-meshheading:15836657-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:15836657-Receptors, Immunologic,
pubmed-meshheading:15836657-Receptors, Scavenger,
pubmed-meshheading:15836657-Sequence Analysis, DNA,
pubmed-meshheading:15836657-Stents
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pubmed:year |
2005
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pubmed:articleTitle |
Severity of coronary artery stenosis is associated with a polymorphism in the CXCL16/SR-PSOX gene.
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pubmed:affiliation |
Department of Caring Sciences, Biomedicine, Orebro University, Orebro, Sweden. gunilla.lundberg@ivo.oru.se <gunilla.lundberg@ivo.oru.se>
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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