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pubmed-article:15835033pubmed:abstractTextFour payload crewmembers were exposed to sustained linear acceleration in a centrifuge during the Neurolab (STS-90) flight. In contrast to previous studies, otolith-ocular reflexes were preserved during and after flight. This raised the possibility that artificial gravity may have acted as a countermeasure to the deconditioning of otolith-ocular reflexes. None of the astronauts who were centrifuged had orthostatic intolerance when tested with head-up passive tilt after flight. Thus, centrifugation may also have helped maintain post-flight hemodynamic responses to orthostasis by preserving the gain of the otolith-sympathetic reflex. A comparison with two fellow Neurolab orbiter crewmembers not exposed to artificial gravity provided some support for this hypothesis. One of the two had hemodynamic changes in response to post-flight tilt similar to orthostatically intolerant subjects from previous missions. More data is necessary to evaluate this hypothesis, but if it were proven correct, in-flight short-radius centrifugation may help counteract orthostatic intolerance after space flight.lld:pubmed
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pubmed-article:15835033pubmed:authorpubmed-author:MooreSteven...lld:pubmed
pubmed-article:15835033pubmed:copyrightInfoc2005 Elsevier Ltd. All rights reserved.lld:pubmed
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pubmed-article:15835033pubmed:volume56lld:pubmed
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pubmed-article:15835033pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:15835033pubmed:articleTitleArtificial gravity: a possible countermeasure for post-flight orthostatic intolerance.lld:pubmed
pubmed-article:15835033pubmed:affiliationDepartment of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA. steven.moore@mssm.edulld:pubmed
pubmed-article:15835033pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15835033pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:15835033pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed