Linked Life Data

15835033

Source:http://linkedlifedata.com/resource/pubmed/id/15835033

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9-12
pubmed:dateCreated
2005-4-18
pubmed:abstractText
Four payload crewmembers were exposed to sustained linear acceleration in a centrifuge during the Neurolab (STS-90) flight. In contrast to previous studies, otolith-ocular reflexes were preserved during and after flight. This raised the possibility that artificial gravity may have acted as a countermeasure to the deconditioning of otolith-ocular reflexes. None of the astronauts who were centrifuged had orthostatic intolerance when tested with head-up passive tilt after flight. Thus, centrifugation may also have helped maintain post-flight hemodynamic responses to orthostasis by preserving the gain of the otolith-sympathetic reflex. A comparison with two fellow Neurolab orbiter crewmembers not exposed to artificial gravity provided some support for this hypothesis. One of the two had hemodynamic changes in response to post-flight tilt similar to orthostatically intolerant subjects from previous missions. More data is necessary to evaluate this hypothesis, but if it were proven correct, in-flight short-radius centrifugation may help counteract orthostatic intolerance after space flight.
pubmed:grant
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
S
pubmed:status
MEDLINE
pubmed:issn
0094-5765
pubmed:author
pubmed:copyrightInfo
c2005 Elsevier Ltd. All rights reserved.
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NASA
pubmed:authorsComplete
Y
pubmed:pagination
867-76
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Artificial gravity: a possible countermeasure for post-flight orthostatic intolerance.
pubmed:affiliation
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA. steven.moore@mssm.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.