Linked Life Data

1582790

Source:http://linkedlifedata.com/resource/pubmed/id/1582790

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1992-6-16
pubmed:abstractText
Retinal leukocyte velocity and density were estimated using blue-field entoptic imaging techniques in a controlled double-masked study to determine the relative effects of oxygen and carbon dioxide on perimacular hemodynamics in single eyes of ten normal human subjects. Mild hypoxia (inspiration of 16% O2) did not significantly alter leukocyte velocity or density from room-air baseline levels. Supplementing 16% oxygen with 5% CO2 produced a tendency toward increased leukocyte velocity (+23%, P = 0.027) with no apparent effect on leukocyte density. Inspiration of pure oxygen was associated with significant reductions in both retinal leukocyte velocity (-20%, P less than 0.007) and density (-23%, P = 0.013) relative to room-air baseline levels. Supplementation of pure oxygen with 5% CO2 appeared to produce a dramatic change in perimacular hemodynamics, tending to increase leukocyte velocity (+26%, P = 0.018) with a limited density change (-11%, P = 0.049). These findings suggest that inspired 5% CO2 can counteract the profound inhibitory effects of excess oxygen on retinal hemodynamics in the functionally important perimacular capillary bed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0146-0404
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1864-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Retinal hemodynamic effects of carbon dioxide, hyperoxia, and mild hypoxia.
pubmed:affiliation
Department of Ophthalmology, University of Wisconsin-Madison.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't