Linked Life Data

1582406

Source:http://linkedlifedata.com/resource/pubmed/id/1582406

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1992-6-16
pubmed:databankReference
pubmed:abstractText
Titin is at present the largest known protein (M(r) 3000 kDa) and its expression is restricted to vertebrate striated muscle. Single molecules span from M- to Z-lines and therefore over 1 micron. We have isolated cDNAs encoding five distant titin A-band epitopes, extended their sequences and determined 30 kb (1000 kDa) of the primary structure of titin. Sequences near the M-line encode a kinase domain and are closely related to the C-terminus of twitchin from Caenorhabditis elegans. This suggests that the function of this region in the titin/twitchin family is conserved throughout the animal kingdom. All other A-band sequences consist of 100 amino acid (aa) repeats predicting immunoglobulin-C2 and fibronectin type III globular domains. These domains are arranged into highly ordered 11 domain super-repeat patterns likely to match the myosin helix repeat in the thick filament. Expressed titin fragments bind to the LMM part of myosin and C-protein. Binding strength increases with the number of domains involved, indicating a cumulative effect of multiple binding sites for myosin along the titin molecule. We conclude that A-band titin is likely to be involved in the ordered assembly of the vertebrate thick filament.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-1860900, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-1910171, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2037050, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2105180, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2117014, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2129545, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2190993, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2199796, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2202734, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2209553, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2315308, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2315320, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2443804, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2453516, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2461560, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2474551, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2482297, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2681227, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-271968, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2726472, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2812002, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2839493, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2985470, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-2999980, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-3030394, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-3058720, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-3253057, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-3282674, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-3320055, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-3326819, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-3342063, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-3537305, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-3542042, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-3740412, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-4802, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-6312838, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-6512859, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-6546423, http://linkedlifedata.com/resource/pubmed/commentcorrection/1582406-6746614
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Calmodulin-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/DNA, http://linkedlifedata.com/resource/pubmed/chemical/Fibronectins, http://linkedlifedata.com/resource/pubmed/chemical/Helminth Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins, http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Myosins, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/connectin, http://linkedlifedata.com/resource/pubmed/chemical/unc-22 protein, C elegans
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1711-6
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
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