Linked Life Data

15822109

Source:http://linkedlifedata.com/resource/pubmed/id/15822109

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-4-18
pubmed:abstractText
Fluctuations in the symptoms of Parkinson's disease (PD), such as wearing-off and on-off effects, and dyskinesias are related to a variety of factors, including duration and dosage of levodopa, age at onset, stress, sleep, food intake, and other pharmacokinetic and pharmacodynamic mechanisms. The majority of patients, particularly those with young onset of PD, experience these levodopa-related adverse effects after a few years of treatment. Assessment of these motor complications is difficult because of the marked clinical variability between and within patients. Daily diaries have been used in clinical trials designed to assess the effects of various pharmacological and surgical interventions on motor fluctuations and dyskinesias. The most common type of dyskinesia, called "peak-dose dyskinesia", usually consists of stereotypical choreic or ballistic movements involving the head, trunk, and limbs, and occasionally, the respiratory muscles, whereas tremor and punding are less-common complications. Dystonia is also typically seen in patients with diphasic dyskinesia and wearing-off effect. Recognition of the full spectrum of clinical phenomenology of levodopa-related motor complications is essential for their treatment and prevention.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0885-3185
pubmed:author
pubmed:copyrightInfo
(c) 2005 Movement Disorder Society.
pubmed:issnType
Print
pubmed:volume
20 Suppl 11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S11-6
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Motor fluctuations and dyskinesias in Parkinson's disease: clinical manifestations.
pubmed:affiliation
Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. josephj@bcm.tmc.edu
pubmed:publicationType
Journal Article, Review